A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat

Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases. Methods: The main objective of this research was to compare the therapeutic eff...

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Autores principales:	A Arzi, M Khalili
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 1999
Materias:	peptic ulcer ulcer index indomethacine pirenzepine ranitidine Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8f4b679d9e1f4efaa2fcda9a150b21ae
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spelling	oai:doaj.org-article:8f4b679d9e1f4efaa2fcda9a150b21ae2021-11-10T09:24:17ZA comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat1561-41072251-7170https://doaj.org/article/8f4b679d9e1f4efaa2fcda9a150b21ae1999-04-01T00:00:00Zhttp://jbums.org/article-1-2954-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases. Methods: The main objective of this research was to compare the therapeutic effects of pirenzepine and ranitidine on peptic ulcer in rats. In this research ulcers were initially induced by oral administration of indomethacin (30 mg/kg) after 72 hours of fasting. Then, pirenzepine (5 mg/kg) and ranitidine (30 mg/kg) were orally administrated for one week. Findings: Then animals were sacrificed and the stomachs removed, the ulcers were measured macroscopically and the ulcer index (2mm) for each stomach was determined. For microscopic studies using H;E staining technique, the slides were prepared. Conclusion: From the macroscopic and microscopic results obtained, it was concluded that ranitidine is more effective than pirenzepine in treatment of peptic ulcer in rats.A ArziM KhaliliBabol University of Medical Sciencesarticlepeptic ulcerulcer indexindomethacinepirenzepineranitidineMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 1, Iss 2, Pp 12-16 (1999)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	peptic ulcer ulcer index indomethacine pirenzepine ranitidine Medicine R Medicine (General) R5-920
spellingShingle	peptic ulcer ulcer index indomethacine pirenzepine ranitidine Medicine R Medicine (General) R5-920 A Arzi M Khalili A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
description	Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases. Methods: The main objective of this research was to compare the therapeutic effects of pirenzepine and ranitidine on peptic ulcer in rats. In this research ulcers were initially induced by oral administration of indomethacin (30 mg/kg) after 72 hours of fasting. Then, pirenzepine (5 mg/kg) and ranitidine (30 mg/kg) were orally administrated for one week. Findings: Then animals were sacrificed and the stomachs removed, the ulcers were measured macroscopically and the ulcer index (2mm) for each stomach was determined. For microscopic studies using H;E staining technique, the slides were prepared. Conclusion: From the macroscopic and microscopic results obtained, it was concluded that ranitidine is more effective than pirenzepine in treatment of peptic ulcer in rats.
format	article
author	A Arzi M Khalili
author_facet	A Arzi M Khalili
author_sort	A Arzi
title	A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
title_short	A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
title_full	A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
title_fullStr	A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
title_full_unstemmed	A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
title_sort	comparative study of pirenzepine and ranitidine effects on treatment of gastric ulcer in rat
publisher	Babol University of Medical Sciences
publishDate	1999
url	https://doaj.org/article/8f4b679d9e1f4efaa2fcda9a150b21ae
work_keys_str_mv	AT aarzi acomparativestudyofpirenzepineandranitidineeffectsontreatmentofgastriculcerinrat AT mkhalili acomparativestudyofpirenzepineandranitidineeffectsontreatmentofgastriculcerinrat AT aarzi comparativestudyofpirenzepineandranitidineeffectsontreatmentofgastriculcerinrat AT mkhalili comparativestudyofpirenzepineandranitidineeffectsontreatmentofgastriculcerinrat
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A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat

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