Spatial distribution of physiologic 12-lead QRS complex

Abstract The normal physiologic range of QRS complex duration spans between 80 and 125 ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal...

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Autores principales:	Katerina Hnatkova, Irena Andršová, Ondřej Toman, Peter Smetana, Katharina M. Huster, Martina Šišáková, Petra Barthel, Tomáš Novotný, Georg Schmidt, Marek Malik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f4db90c66bd4b92819ff0064a729459
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spelling	oai:doaj.org-article:8f4db90c66bd4b92819ff0064a7294592021-12-02T16:23:18ZSpatial distribution of physiologic 12-lead QRS complex10.1038/s41598-021-83378-82045-2322https://doaj.org/article/8f4db90c66bd4b92819ff0064a7294592021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83378-8https://doaj.org/toc/2045-2322Abstract The normal physiologic range of QRS complex duration spans between 80 and 125 ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. The technology was applied to 382,019 individual 10-s ECG samples recorded in 639 healthy subjects (311 females and 328 males) aged 33.8 ± 9.4 years. The analyses showed that QRS duration was mainly influenced by the proportions of the first two orthogonal components of the QRS complex. The first component demonstrated statistically significantly larger proportion of the total QRS power (expressed by the absolute area of the complex in all independent ECG leads) in females than in males (64.2 ± 11.6% vs 59.7 ± 11.9%, p < 0.00001—measured at resting heart rate of 60 beats per minute) while the second component demonstrated larger proportion of the QRS power in males compared to females (33.1 ± 11.9% vs 29.6 ± 11.4%, p < 0.001). The analysis also showed that the components attributable to localised depolarisation sequence abnormalities were significantly larger in males compared to females (2.85 ± 1.08% vs 2.42 ± 0.87%, p < 0.00001). In addition to the demonstration of the technology, the study concludes that the detailed convolution of the depolarisation waveform is individual, and that smoother and less intricate depolarisation propagation is the mechanism likely responsible for shorter QRS duration in females.Katerina HnatkovaIrena AndršováOndřej TomanPeter SmetanaKatharina M. HusterMartina ŠišákováPetra BarthelTomáš NovotnýGeorg SchmidtMarek MalikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katerina Hnatkova Irena Andršová Ondřej Toman Peter Smetana Katharina M. Huster Martina Šišáková Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik Spatial distribution of physiologic 12-lead QRS complex
description	Abstract The normal physiologic range of QRS complex duration spans between 80 and 125 ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. The technology was applied to 382,019 individual 10-s ECG samples recorded in 639 healthy subjects (311 females and 328 males) aged 33.8 ± 9.4 years. The analyses showed that QRS duration was mainly influenced by the proportions of the first two orthogonal components of the QRS complex. The first component demonstrated statistically significantly larger proportion of the total QRS power (expressed by the absolute area of the complex in all independent ECG leads) in females than in males (64.2 ± 11.6% vs 59.7 ± 11.9%, p < 0.00001—measured at resting heart rate of 60 beats per minute) while the second component demonstrated larger proportion of the QRS power in males compared to females (33.1 ± 11.9% vs 29.6 ± 11.4%, p < 0.001). The analysis also showed that the components attributable to localised depolarisation sequence abnormalities were significantly larger in males compared to females (2.85 ± 1.08% vs 2.42 ± 0.87%, p < 0.00001). In addition to the demonstration of the technology, the study concludes that the detailed convolution of the depolarisation waveform is individual, and that smoother and less intricate depolarisation propagation is the mechanism likely responsible for shorter QRS duration in females.
format	article
author	Katerina Hnatkova Irena Andršová Ondřej Toman Peter Smetana Katharina M. Huster Martina Šišáková Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_facet	Katerina Hnatkova Irena Andršová Ondřej Toman Peter Smetana Katharina M. Huster Martina Šišáková Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_sort	Katerina Hnatkova
title	Spatial distribution of physiologic 12-lead QRS complex
title_short	Spatial distribution of physiologic 12-lead QRS complex
title_full	Spatial distribution of physiologic 12-lead QRS complex
title_fullStr	Spatial distribution of physiologic 12-lead QRS complex
title_full_unstemmed	Spatial distribution of physiologic 12-lead QRS complex
title_sort	spatial distribution of physiologic 12-lead qrs complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f4db90c66bd4b92819ff0064a729459
work_keys_str_mv	AT katerinahnatkova spatialdistributionofphysiologic12leadqrscomplex AT irenaandrsova spatialdistributionofphysiologic12leadqrscomplex AT ondrejtoman spatialdistributionofphysiologic12leadqrscomplex AT petersmetana spatialdistributionofphysiologic12leadqrscomplex AT katharinamhuster spatialdistributionofphysiologic12leadqrscomplex AT martinasisakova spatialdistributionofphysiologic12leadqrscomplex AT petrabarthel spatialdistributionofphysiologic12leadqrscomplex AT tomasnovotny spatialdistributionofphysiologic12leadqrscomplex AT georgschmidt spatialdistributionofphysiologic12leadqrscomplex AT marekmalik spatialdistributionofphysiologic12leadqrscomplex
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Spatial distribution of physiologic 12-lead QRS complex

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