Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Abstract Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function polymorphisms in hTPC2 are associated with decreased melanin production and blond hair color. Vice versa genetic ablation of TPC2...

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Autores principales: Ponsawan Netcharoensirisuk, Carla Abrahamian, Rachel Tang, Cheng-Chang Chen, Anna Scotto Rosato, Wyatt Beyers, Yu-Kai Chao, Antonio Filippini, Santiago Di Pietro, Karin Bartel, Martin Biel, Angelika M. Vollmar, Kaoru Umehara, Wanchai De-Eknamkul, Christian Grimm
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/8f4de751c6ed48b481f4c92a2999702f
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https://doaj.org/article/8f4de751c6ed48b481f4c92a2999702f

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