A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke

Abstract Observational studies have shown that several risk factors are associated with cardioembolic stroke. However, whether such associations reflect causality remains unknown. We aimed to determine whether established and provisional cardioembolic risk factors are causally associated with cardio...

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Autores principales:	Danyang Tian, Linjing Zhang, Zhenhuang Zhuang, Tao Huang, Dongsheng Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f4ed8e2873d4f368a3117b4d00595d1
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spelling	oai:doaj.org-article:8f4ed8e2873d4f368a3117b4d00595d12021-12-02T16:14:03ZA Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke10.1038/s41598-021-93979-y2045-2322https://doaj.org/article/8f4ed8e2873d4f368a3117b4d00595d12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93979-yhttps://doaj.org/toc/2045-2322Abstract Observational studies have shown that several risk factors are associated with cardioembolic stroke. However, whether such associations reflect causality remains unknown. We aimed to determine whether established and provisional cardioembolic risk factors are causally associated with cardioembolic stroke. Genetic instruments for atrial fibrillation (AF), myocardial infarction (MI), electrocardiogram (ECG) indices and N-terminal pro-brain natriuretic peptide (NT-pro BNP) were obtained from large genetic consortiums. Summarized data of ischemic stroke and its subtypes were extracted from the MEGASTROKE consortium. Causal estimates were calculated by applying inverse-variance weighted analysis, weighted median analysis, simple median analysis and Mendelian randomization (MR)-Egger regression. Genetically predicted AF was significantly associated with higher odds of ischemic stroke (odds ratio (OR): 1.20, 95% confidence intervals (CI): 1.16–1.24, P = 6.53 × 10–30) and cardioembolic stroke (OR: 1.95, 95% CI: 1.85–2.06, P = 8.81 × 10–125). Suggestive associations were found between genetically determined resting heart rate and higher odds of ischemic stroke (OR: 1.01, 95% CI: 1.00–1.02, P = 0.005), large-artery atherosclerotic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.026) and cardioembolic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.028). There was no causal association of P‐wave terminal force in the precordial lead V1 (PTFVI), P-wave duration (PWD), NT-pro BNP or PR interval with ischemic stroke or any subtype.Danyang TianLinjing ZhangZhenhuang ZhuangTao HuangDongsheng FanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
description	Abstract Observational studies have shown that several risk factors are associated with cardioembolic stroke. However, whether such associations reflect causality remains unknown. We aimed to determine whether established and provisional cardioembolic risk factors are causally associated with cardioembolic stroke. Genetic instruments for atrial fibrillation (AF), myocardial infarction (MI), electrocardiogram (ECG) indices and N-terminal pro-brain natriuretic peptide (NT-pro BNP) were obtained from large genetic consortiums. Summarized data of ischemic stroke and its subtypes were extracted from the MEGASTROKE consortium. Causal estimates were calculated by applying inverse-variance weighted analysis, weighted median analysis, simple median analysis and Mendelian randomization (MR)-Egger regression. Genetically predicted AF was significantly associated with higher odds of ischemic stroke (odds ratio (OR): 1.20, 95% confidence intervals (CI): 1.16–1.24, P = 6.53 × 10–30) and cardioembolic stroke (OR: 1.95, 95% CI: 1.85–2.06, P = 8.81 × 10–125). Suggestive associations were found between genetically determined resting heart rate and higher odds of ischemic stroke (OR: 1.01, 95% CI: 1.00–1.02, P = 0.005), large-artery atherosclerotic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.026) and cardioembolic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.028). There was no causal association of P‐wave terminal force in the precordial lead V1 (PTFVI), P-wave duration (PWD), NT-pro BNP or PR interval with ischemic stroke or any subtype.
format	article
author	Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan
author_facet	Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan
author_sort	Danyang Tian
title	A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
title_short	A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
title_full	A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
title_fullStr	A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
title_full_unstemmed	A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
title_sort	mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f4ed8e2873d4f368a3117b4d00595d1
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A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke

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