Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor for predator odor-evoked innate fear and defensive...

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Autores principales: Yibing Wang, Liqin Cao, Chia-Ying Lee, Tomohiko Matsuo, Kejia Wu, Greg Asher, Lijun Tang, Tsuyoshi Saitoh, Jamie Russell, Daniela Klewe-Nebenius, Li Wang, Shingo Soya, Emi Hasegawa, Yoan Chérasse, Jiamin Zhou, Yuwenbin Li, Tao Wang, Xiaowei Zhan, Chika Miyoshi, Yoko Irukayama, Jie Cao, Julian P. Meeks, Laurent Gautron, Zhiqiang Wang, Katsuyasu Sakurai, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa, Hiroshi Nagase, Reiko Kobayakawa, Ko Kobayakawa, Bruce Beutler, Qinghua Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8f55e531aa4244bb85f1b7f3abfc81f3
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spelling oai:doaj.org-article:8f55e531aa4244bb85f1b7f3abfc81f32021-12-02T17:31:15ZLarge-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors10.1038/s41467-018-04324-32041-1723https://doaj.org/article/8f55e531aa4244bb85f1b7f3abfc81f32018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04324-3https://doaj.org/toc/2041-1723TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor for predator odor-evoked innate fear and defensive behaviors.Yibing WangLiqin CaoChia-Ying LeeTomohiko MatsuoKejia WuGreg AsherLijun TangTsuyoshi SaitohJamie RussellDaniela Klewe-NebeniusLi WangShingo SoyaEmi HasegawaYoan ChérasseJiamin ZhouYuwenbin LiTao WangXiaowei ZhanChika MiyoshiYoko IrukayamaJie CaoJulian P. MeeksLaurent GautronZhiqiang WangKatsuyasu SakuraiHiromasa FunatoTakeshi SakuraiMasashi YanagisawaHiroshi NagaseReiko KobayakawaKo KobayakawaBruce BeutlerQinghua LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yibing Wang
Liqin Cao
Chia-Ying Lee
Tomohiko Matsuo
Kejia Wu
Greg Asher
Lijun Tang
Tsuyoshi Saitoh
Jamie Russell
Daniela Klewe-Nebenius
Li Wang
Shingo Soya
Emi Hasegawa
Yoan Chérasse
Jiamin Zhou
Yuwenbin Li
Tao Wang
Xiaowei Zhan
Chika Miyoshi
Yoko Irukayama
Jie Cao
Julian P. Meeks
Laurent Gautron
Zhiqiang Wang
Katsuyasu Sakurai
Hiromasa Funato
Takeshi Sakurai
Masashi Yanagisawa
Hiroshi Nagase
Reiko Kobayakawa
Ko Kobayakawa
Bruce Beutler
Qinghua Liu
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
description TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor for predator odor-evoked innate fear and defensive behaviors.
format article
author Yibing Wang
Liqin Cao
Chia-Ying Lee
Tomohiko Matsuo
Kejia Wu
Greg Asher
Lijun Tang
Tsuyoshi Saitoh
Jamie Russell
Daniela Klewe-Nebenius
Li Wang
Shingo Soya
Emi Hasegawa
Yoan Chérasse
Jiamin Zhou
Yuwenbin Li
Tao Wang
Xiaowei Zhan
Chika Miyoshi
Yoko Irukayama
Jie Cao
Julian P. Meeks
Laurent Gautron
Zhiqiang Wang
Katsuyasu Sakurai
Hiromasa Funato
Takeshi Sakurai
Masashi Yanagisawa
Hiroshi Nagase
Reiko Kobayakawa
Ko Kobayakawa
Bruce Beutler
Qinghua Liu
author_facet Yibing Wang
Liqin Cao
Chia-Ying Lee
Tomohiko Matsuo
Kejia Wu
Greg Asher
Lijun Tang
Tsuyoshi Saitoh
Jamie Russell
Daniela Klewe-Nebenius
Li Wang
Shingo Soya
Emi Hasegawa
Yoan Chérasse
Jiamin Zhou
Yuwenbin Li
Tao Wang
Xiaowei Zhan
Chika Miyoshi
Yoko Irukayama
Jie Cao
Julian P. Meeks
Laurent Gautron
Zhiqiang Wang
Katsuyasu Sakurai
Hiromasa Funato
Takeshi Sakurai
Masashi Yanagisawa
Hiroshi Nagase
Reiko Kobayakawa
Ko Kobayakawa
Bruce Beutler
Qinghua Liu
author_sort Yibing Wang
title Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
title_short Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
title_full Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
title_fullStr Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
title_full_unstemmed Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
title_sort large-scale forward genetics screening identifies trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8f55e531aa4244bb85f1b7f3abfc81f3
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