The Metabolic Control of Myeloid Cells in the Tumor Microenvironment

Myeloid cells are a key determinant of tumor progression and patient outcomes in a range of cancers and are therefore being actively pursued as targets of new immunotherapies. The recent use of high-dimensional single-cell approaches, e.g., mass cytometry and single-cell RNA-sequencing (scRNA-seq) h...

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Autores principales:	Eloise Ramel, Sebastian Lillo, Boutaina Daher, Marina Fioleau, Thomas Daubon, Maya Saleh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cellular metabolism immunometabolism myeloid cells macrophages tumor microenvironment cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8f57e36c95fc41128b29b93698117b9f
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id	oai:doaj.org-article:8f57e36c95fc41128b29b93698117b9f
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spelling	oai:doaj.org-article:8f57e36c95fc41128b29b93698117b9f2021-11-25T17:09:50ZThe Metabolic Control of Myeloid Cells in the Tumor Microenvironment10.3390/cells101129602073-4409https://doaj.org/article/8f57e36c95fc41128b29b93698117b9f2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2960https://doaj.org/toc/2073-4409Myeloid cells are a key determinant of tumor progression and patient outcomes in a range of cancers and are therefore being actively pursued as targets of new immunotherapies. The recent use of high-dimensional single-cell approaches, e.g., mass cytometry and single-cell RNA-sequencing (scRNA-seq) has reinforced the predominance of myeloid cells in the tumor microenvironment and uncovered their phenotypic diversity in different cancers. The cancerous metabolic environment has emerged as a critical modulator of myeloid cell functions in anti-tumor immunity versus immune suppression and immune evasion. Here, we discuss mechanisms of immune-metabolic crosstalk in tumorigenesis, with a particular focus on the tumor-associated myeloid cell’s metabolic programs. We highlight the impact of several metabolic pathways on the pro-tumoral functions of tumor-associated macrophages and myeloid-derived suppressor cells and discuss the potential myeloid cell metabolic checkpoints for cancer immunotherapy, either as monotherapies or in combination with other immunotherapies.Eloise RamelSebastian LilloBoutaina DaherMarina FioleauThomas DaubonMaya SalehMDPI AGarticlecellular metabolismimmunometabolismmyeloid cellsmacrophagestumor microenvironmentcancerBiology (General)QH301-705.5ENCells, Vol 10, Iss 2960, p 2960 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cellular metabolism immunometabolism myeloid cells macrophages tumor microenvironment cancer Biology (General) QH301-705.5
spellingShingle	cellular metabolism immunometabolism myeloid cells macrophages tumor microenvironment cancer Biology (General) QH301-705.5 Eloise Ramel Sebastian Lillo Boutaina Daher Marina Fioleau Thomas Daubon Maya Saleh The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
description	Myeloid cells are a key determinant of tumor progression and patient outcomes in a range of cancers and are therefore being actively pursued as targets of new immunotherapies. The recent use of high-dimensional single-cell approaches, e.g., mass cytometry and single-cell RNA-sequencing (scRNA-seq) has reinforced the predominance of myeloid cells in the tumor microenvironment and uncovered their phenotypic diversity in different cancers. The cancerous metabolic environment has emerged as a critical modulator of myeloid cell functions in anti-tumor immunity versus immune suppression and immune evasion. Here, we discuss mechanisms of immune-metabolic crosstalk in tumorigenesis, with a particular focus on the tumor-associated myeloid cell’s metabolic programs. We highlight the impact of several metabolic pathways on the pro-tumoral functions of tumor-associated macrophages and myeloid-derived suppressor cells and discuss the potential myeloid cell metabolic checkpoints for cancer immunotherapy, either as monotherapies or in combination with other immunotherapies.
format	article
author	Eloise Ramel Sebastian Lillo Boutaina Daher Marina Fioleau Thomas Daubon Maya Saleh
author_facet	Eloise Ramel Sebastian Lillo Boutaina Daher Marina Fioleau Thomas Daubon Maya Saleh
author_sort	Eloise Ramel
title	The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
title_short	The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
title_full	The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
title_fullStr	The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
title_full_unstemmed	The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
title_sort	metabolic control of myeloid cells in the tumor microenvironment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f57e36c95fc41128b29b93698117b9f
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The Metabolic Control of Myeloid Cells in the Tumor Microenvironment

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