Association of incremental pulse wave velocity with cardiometabolic risk factors

Abstract We investigate the association of incremental pulse wave velocity (ΔC; the change in pulse wave velocity over a cardiac cycle) with cardiometabolic risk factors and report the first and (currently) the largest population-level data. In a cross-sectional study performed in a cohort of 1373 g...

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Autores principales:	P. M. Nabeel, Dinu S. Chandran, Prabhdeep Kaur, Sadagopan Thanikachalam, Mohanasankar Sivaprakasam, Jayaraj Joseph
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f5883df1c544a22b87a0b3bf1287a25
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spelling	oai:doaj.org-article:8f5883df1c544a22b87a0b3bf1287a252021-12-02T16:06:43ZAssociation of incremental pulse wave velocity with cardiometabolic risk factors10.1038/s41598-021-94723-22045-2322https://doaj.org/article/8f5883df1c544a22b87a0b3bf1287a252021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94723-2https://doaj.org/toc/2045-2322Abstract We investigate the association of incremental pulse wave velocity (ΔC; the change in pulse wave velocity over a cardiac cycle) with cardiometabolic risk factors and report the first and (currently) the largest population-level data. In a cross-sectional study performed in a cohort of 1373 general population participants, ΔC was measured using clinically validated ARTSENS devices. There were 455 participants in the metabolic syndrome (MetS) group whose average ΔC was ~ 28.4% higher than that of the non-metabolic syndrome (Non-MetS) group. Females with MetS showed ~ 10.9% elevated average ΔC compared to males of the Non-MetS group. As the number of risk factors increased from 0 to 5, the average ΔC escalated by ~ 55% (1.50 ± 0.52 m/s to 2.33 ± 0.91 m/s). A gradual increase in average ΔC was observed across each decade from the younger (ΔC = 1.53 ± 0.54 m/s) to geriatric (ΔC = 2.34 ± 0.59 m/s) populations. There was also a significant difference in ΔC among the blood pressure categories. Most importantly, ΔC ≥ 1.81 m/s predicted a constellation of ≥ 3 risks with AUC = 0.615, OR = 2.309, and RR = 1.703. All statistical trends remained significant, even after adjusting for covariates. The study provides initial evidence for the potential use of ΔC as a tool for the early detection and screening of vascular dysfunction, which opens up avenues for active clinical and epidemiological studies. Further investigations are encouraged to confirm and establish the causative mechanism for the reported associations.P. M. NabeelDinu S. ChandranPrabhdeep KaurSadagopan ThanikachalamMohanasankar SivaprakasamJayaraj JosephNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P. M. Nabeel Dinu S. Chandran Prabhdeep Kaur Sadagopan Thanikachalam Mohanasankar Sivaprakasam Jayaraj Joseph Association of incremental pulse wave velocity with cardiometabolic risk factors
description	Abstract We investigate the association of incremental pulse wave velocity (ΔC; the change in pulse wave velocity over a cardiac cycle) with cardiometabolic risk factors and report the first and (currently) the largest population-level data. In a cross-sectional study performed in a cohort of 1373 general population participants, ΔC was measured using clinically validated ARTSENS devices. There were 455 participants in the metabolic syndrome (MetS) group whose average ΔC was ~ 28.4% higher than that of the non-metabolic syndrome (Non-MetS) group. Females with MetS showed ~ 10.9% elevated average ΔC compared to males of the Non-MetS group. As the number of risk factors increased from 0 to 5, the average ΔC escalated by ~ 55% (1.50 ± 0.52 m/s to 2.33 ± 0.91 m/s). A gradual increase in average ΔC was observed across each decade from the younger (ΔC = 1.53 ± 0.54 m/s) to geriatric (ΔC = 2.34 ± 0.59 m/s) populations. There was also a significant difference in ΔC among the blood pressure categories. Most importantly, ΔC ≥ 1.81 m/s predicted a constellation of ≥ 3 risks with AUC = 0.615, OR = 2.309, and RR = 1.703. All statistical trends remained significant, even after adjusting for covariates. The study provides initial evidence for the potential use of ΔC as a tool for the early detection and screening of vascular dysfunction, which opens up avenues for active clinical and epidemiological studies. Further investigations are encouraged to confirm and establish the causative mechanism for the reported associations.
format	article
author	P. M. Nabeel Dinu S. Chandran Prabhdeep Kaur Sadagopan Thanikachalam Mohanasankar Sivaprakasam Jayaraj Joseph
author_facet	P. M. Nabeel Dinu S. Chandran Prabhdeep Kaur Sadagopan Thanikachalam Mohanasankar Sivaprakasam Jayaraj Joseph
author_sort	P. M. Nabeel
title	Association of incremental pulse wave velocity with cardiometabolic risk factors
title_short	Association of incremental pulse wave velocity with cardiometabolic risk factors
title_full	Association of incremental pulse wave velocity with cardiometabolic risk factors
title_fullStr	Association of incremental pulse wave velocity with cardiometabolic risk factors
title_full_unstemmed	Association of incremental pulse wave velocity with cardiometabolic risk factors
title_sort	association of incremental pulse wave velocity with cardiometabolic risk factors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f5883df1c544a22b87a0b3bf1287a25
work_keys_str_mv	AT pmnabeel associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors AT dinuschandran associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors AT prabhdeepkaur associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors AT sadagopanthanikachalam associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors AT mohanasankarsivaprakasam associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors AT jayarajjoseph associationofincrementalpulsewavevelocitywithcardiometabolicriskfactors
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Association of incremental pulse wave velocity with cardiometabolic risk factors

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