Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and infl...
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Nature Portfolio
2018
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oai:doaj.org-article:8f5b1e43017943509f14b4b68fe07ec52021-12-02T17:31:46ZEndogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase10.1038/s41467-018-06158-52041-1723https://doaj.org/article/8f5b1e43017943509f14b4b68fe07ec52018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06158-5https://doaj.org/toc/2041-1723Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses.Helmut PeinAlexia VilleSimona PaceVeronika TemmlUlrike GarschaMartin RaaschKhaled AlsabilGuillaume ViaultChau-Phi DinhDavid GuiletFabiana TroisiKonstantin NeukirchStefanie KönigRosella BilanciaBirgit WaltenbergerHermann StuppnerMaria WallertStefan LorkowskiChristina WeinigelSilke RummlerMarc BirringerFiorentina RoviezzoLidia SautebinJean-Jacques HelesbeuxDenis SéraphinAlexander S. MosigDaniela SchusterAntonietta RossiPascal RichommeOliver WerzAndreas KoeberleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
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Science Q Helmut Pein Alexia Ville Simona Pace Veronika Temml Ulrike Garscha Martin Raasch Khaled Alsabil Guillaume Viault Chau-Phi Dinh David Guilet Fabiana Troisi Konstantin Neukirch Stefanie König Rosella Bilancia Birgit Waltenberger Hermann Stuppner Maria Wallert Stefan Lorkowski Christina Weinigel Silke Rummler Marc Birringer Fiorentina Roviezzo Lidia Sautebin Jean-Jacques Helesbeux Denis Séraphin Alexander S. Mosig Daniela Schuster Antonietta Rossi Pascal Richomme Oliver Werz Andreas Koeberle Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| description |
Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses. |
| format |
article |
| author |
Helmut Pein Alexia Ville Simona Pace Veronika Temml Ulrike Garscha Martin Raasch Khaled Alsabil Guillaume Viault Chau-Phi Dinh David Guilet Fabiana Troisi Konstantin Neukirch Stefanie König Rosella Bilancia Birgit Waltenberger Hermann Stuppner Maria Wallert Stefan Lorkowski Christina Weinigel Silke Rummler Marc Birringer Fiorentina Roviezzo Lidia Sautebin Jean-Jacques Helesbeux Denis Séraphin Alexander S. Mosig Daniela Schuster Antonietta Rossi Pascal Richomme Oliver Werz Andreas Koeberle |
| author_facet |
Helmut Pein Alexia Ville Simona Pace Veronika Temml Ulrike Garscha Martin Raasch Khaled Alsabil Guillaume Viault Chau-Phi Dinh David Guilet Fabiana Troisi Konstantin Neukirch Stefanie König Rosella Bilancia Birgit Waltenberger Hermann Stuppner Maria Wallert Stefan Lorkowski Christina Weinigel Silke Rummler Marc Birringer Fiorentina Roviezzo Lidia Sautebin Jean-Jacques Helesbeux Denis Séraphin Alexander S. Mosig Daniela Schuster Antonietta Rossi Pascal Richomme Oliver Werz Andreas Koeberle |
| author_sort |
Helmut Pein |
| title |
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| title_short |
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| title_full |
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| title_fullStr |
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| title_full_unstemmed |
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase |
| title_sort |
endogenous metabolites of vitamin e limit inflammation by targeting 5-lipoxygenase |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8f5b1e43017943509f14b4b68fe07ec5 |
| work_keys_str_mv |
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