Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

Modelling and visualizing tumor metastasis in Drosophila has been a challenge. Here, the authors show that constitutive expression of Sna in primary adult Drosophila intestinal tumors drives EMT and dissemination of tumor cells, induces collective cell migration and formation of polyclonal metastase...

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Autores principales:	Kyra Campbell, Fabrizio Rossi, Jamie Adams, Ioanna Pitsidianaki, Francisco M. Barriga, Laura Garcia-Gerique, Eduard Batlle, Jordi Casanova, Andreu Casali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f5e51cdd6d84027b66d19cd733b9143
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spelling	oai:doaj.org-article:8f5e51cdd6d84027b66d19cd733b91432021-12-02T16:58:13ZCollective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors10.1038/s41467-019-10269-y2041-1723https://doaj.org/article/8f5e51cdd6d84027b66d19cd733b91432019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10269-yhttps://doaj.org/toc/2041-1723Modelling and visualizing tumor metastasis in Drosophila has been a challenge. Here, the authors show that constitutive expression of Sna in primary adult Drosophila intestinal tumors drives EMT and dissemination of tumor cells, induces collective cell migration and formation of polyclonal metastases.Kyra CampbellFabrizio RossiJamie AdamsIoanna PitsidianakiFrancisco M. BarrigaLaura Garcia-GeriqueEduard BatlleJordi CasanovaAndreu CasaliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyra Campbell Fabrizio Rossi Jamie Adams Ioanna Pitsidianaki Francisco M. Barriga Laura Garcia-Gerique Eduard Batlle Jordi Casanova Andreu Casali Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
description	Modelling and visualizing tumor metastasis in Drosophila has been a challenge. Here, the authors show that constitutive expression of Sna in primary adult Drosophila intestinal tumors drives EMT and dissemination of tumor cells, induces collective cell migration and formation of polyclonal metastases.
format	article
author	Kyra Campbell Fabrizio Rossi Jamie Adams Ioanna Pitsidianaki Francisco M. Barriga Laura Garcia-Gerique Eduard Batlle Jordi Casanova Andreu Casali
author_facet	Kyra Campbell Fabrizio Rossi Jamie Adams Ioanna Pitsidianaki Francisco M. Barriga Laura Garcia-Gerique Eduard Batlle Jordi Casanova Andreu Casali
author_sort	Kyra Campbell
title	Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
title_short	Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
title_full	Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
title_fullStr	Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
title_full_unstemmed	Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
title_sort	collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in drosophila intestinal tumors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8f5e51cdd6d84027b66d19cd733b9143
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Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

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