Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

Modelling and visualizing tumor metastasis in Drosophila has been a challenge. Here, the authors show that constitutive expression of Sna in primary adult Drosophila intestinal tumors drives EMT and dissemination of tumor cells, induces collective cell migration and formation of polyclonal metastase...

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Autores principales: Kyra Campbell, Fabrizio Rossi, Jamie Adams, Ioanna Pitsidianaki, Francisco M. Barriga, Laura Garcia-Gerique, Eduard Batlle, Jordi Casanova, Andreu Casali
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/8f5e51cdd6d84027b66d19cd733b9143
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