iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.

<h4>Background</h4>CD1d-restricted invariant NKT (iNKT) cells are a subset of T lymphocytes endowed with innate effector functions that aid in the establishment of adaptive T and B cell immune responses. iNKT cells have been shown to play a spontaneous protective role against experimenta...

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Autores principales:	Matteo Bellone, Monica Ceccon, Matteo Grioni, Elena Jachetti, Arianna Calcinotto, Anna Napolitano, Massimo Freschi, Giulia Casorati, Paolo Dellabona
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f5ef6a07dc04f829fc6828875c34a0a
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spelling	oai:doaj.org-article:8f5ef6a07dc04f829fc6828875c34a0a2021-11-25T06:26:48ZiNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.1932-620310.1371/journal.pone.0008646https://doaj.org/article/8f5ef6a07dc04f829fc6828875c34a0a2010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20072624/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>CD1d-restricted invariant NKT (iNKT) cells are a subset of T lymphocytes endowed with innate effector functions that aid in the establishment of adaptive T and B cell immune responses. iNKT cells have been shown to play a spontaneous protective role against experimental tumors. Yet, the interplay between iNKT and tumor-specific T cells in cancer immune surveillance/editing has never been addressed. The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a realistic model of spontaneous oncogenesis, in which the tumor-specific cytotoxic T cell (CTL) response undergoes full tolerance upon disease progression.<h4>Principal findings</h4>We report here that lack of iNKT cells in TRAMP mice resulted in the appearance of more precocious and aggressive tumors that significantly reduced animal survival. TRAMP mice bearing or lacking iNKT cells responded similarly to a tumor-specific vaccination and developed tolerance to a tumor-associated antigen at comparable rate.<h4>Conclusions</h4>Hence, our data argue for a critical role of iNKT cells in the immune surveillance of carcinoma that is independent of tumor-specific CTL.Matteo BelloneMonica CecconMatteo GrioniElena JachettiArianna CalcinottoAnna NapolitanoMassimo FreschiGiulia CasoratiPaolo DellabonaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 1, p e8646 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matteo Bellone Monica Ceccon Matteo Grioni Elena Jachetti Arianna Calcinotto Anna Napolitano Massimo Freschi Giulia Casorati Paolo Dellabona iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
description	<h4>Background</h4>CD1d-restricted invariant NKT (iNKT) cells are a subset of T lymphocytes endowed with innate effector functions that aid in the establishment of adaptive T and B cell immune responses. iNKT cells have been shown to play a spontaneous protective role against experimental tumors. Yet, the interplay between iNKT and tumor-specific T cells in cancer immune surveillance/editing has never been addressed. The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a realistic model of spontaneous oncogenesis, in which the tumor-specific cytotoxic T cell (CTL) response undergoes full tolerance upon disease progression.<h4>Principal findings</h4>We report here that lack of iNKT cells in TRAMP mice resulted in the appearance of more precocious and aggressive tumors that significantly reduced animal survival. TRAMP mice bearing or lacking iNKT cells responded similarly to a tumor-specific vaccination and developed tolerance to a tumor-associated antigen at comparable rate.<h4>Conclusions</h4>Hence, our data argue for a critical role of iNKT cells in the immune surveillance of carcinoma that is independent of tumor-specific CTL.
format	article
author	Matteo Bellone Monica Ceccon Matteo Grioni Elena Jachetti Arianna Calcinotto Anna Napolitano Massimo Freschi Giulia Casorati Paolo Dellabona
author_facet	Matteo Bellone Monica Ceccon Matteo Grioni Elena Jachetti Arianna Calcinotto Anna Napolitano Massimo Freschi Giulia Casorati Paolo Dellabona
author_sort	Matteo Bellone
title	iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
title_short	iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
title_full	iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
title_fullStr	iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
title_full_unstemmed	iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.
title_sort	inkt cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic t cells.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/8f5ef6a07dc04f829fc6828875c34a0a
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iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.

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