Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer

Peritoneal spread is frequent in gastric cancer (GC) and a palliative condition. After failure to systemic chemotherapy (sCTx) remaining therapeutic options are very limited. We evaluated the feasibility and efficacy of locoregional chemotherapy (RegCTx) in peritoneal metastatic GC. In total, 38 (23...

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Autores principales:	Kornelia Aigner, Yogesh Kumar Vashist, Emir Selak, Sabine Gailhofer, Karl Reinhard Aigner
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	regional chemotherapy isolated abdominal perfusion intra-arterial infusion stop-flow perfusion peritoneal carcinomatosis gastric cancer Medicine R
Acceso en línea:	https://doaj.org/article/8f5fd060eec74406902f2b471df6eb90
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spelling	oai:doaj.org-article:8f5fd060eec74406902f2b471df6eb902021-11-25T18:01:45ZEfficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer10.3390/jcm102253222077-0383https://doaj.org/article/8f5fd060eec74406902f2b471df6eb902021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5322https://doaj.org/toc/2077-0383Peritoneal spread is frequent in gastric cancer (GC) and a palliative condition. After failure to systemic chemotherapy (sCTx) remaining therapeutic options are very limited. We evaluated the feasibility and efficacy of locoregional chemotherapy (RegCTx) in peritoneal metastatic GC. In total, 38 (23 male and 15 female) patients with peritoneal metastatic GC after failure of previous sCTx and unresectable disease were enrolled in this study. Using the hypoxic abdominal stop-flow perfusion, upper abdominal perfusion and intraarterial infusion technique in total 114 cycles with Cisplatin, Adriamycin and Mitomycin C were applied. No significant procedure related toxicity was noticed- especially no Grade 3 or 4 toxicity occurred. With the RegCTx approach a median overall survival of 17.4 months was achieved. Patients who had undergone previously resection of the GC the median overall survival was even better with 23.5 months. RegCTx is a promising, safe and efficient approach in diffuse metastatic GC. The evaluation of RegCTx in the setting of multimodal treatment approach at less advanced stages is also warranted.Kornelia AignerYogesh Kumar VashistEmir SelakSabine GailhoferKarl Reinhard AignerMDPI AGarticleregional chemotherapyisolated abdominal perfusionintra-arterial infusionstop-flow perfusionperitoneal carcinomatosisgastric cancerMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5322, p 5322 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	regional chemotherapy isolated abdominal perfusion intra-arterial infusion stop-flow perfusion peritoneal carcinomatosis gastric cancer Medicine R
spellingShingle	regional chemotherapy isolated abdominal perfusion intra-arterial infusion stop-flow perfusion peritoneal carcinomatosis gastric cancer Medicine R Kornelia Aigner Yogesh Kumar Vashist Emir Selak Sabine Gailhofer Karl Reinhard Aigner Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
description	Peritoneal spread is frequent in gastric cancer (GC) and a palliative condition. After failure to systemic chemotherapy (sCTx) remaining therapeutic options are very limited. We evaluated the feasibility and efficacy of locoregional chemotherapy (RegCTx) in peritoneal metastatic GC. In total, 38 (23 male and 15 female) patients with peritoneal metastatic GC after failure of previous sCTx and unresectable disease were enrolled in this study. Using the hypoxic abdominal stop-flow perfusion, upper abdominal perfusion and intraarterial infusion technique in total 114 cycles with Cisplatin, Adriamycin and Mitomycin C were applied. No significant procedure related toxicity was noticed- especially no Grade 3 or 4 toxicity occurred. With the RegCTx approach a median overall survival of 17.4 months was achieved. Patients who had undergone previously resection of the GC the median overall survival was even better with 23.5 months. RegCTx is a promising, safe and efficient approach in diffuse metastatic GC. The evaluation of RegCTx in the setting of multimodal treatment approach at less advanced stages is also warranted.
format	article
author	Kornelia Aigner Yogesh Kumar Vashist Emir Selak Sabine Gailhofer Karl Reinhard Aigner
author_facet	Kornelia Aigner Yogesh Kumar Vashist Emir Selak Sabine Gailhofer Karl Reinhard Aigner
author_sort	Kornelia Aigner
title	Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
title_short	Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
title_full	Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
title_fullStr	Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
title_full_unstemmed	Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer
title_sort	efficacy of regional chemotherapy approach in peritoneal metastatic gastric cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f5fd060eec74406902f2b471df6eb90
work_keys_str_mv	AT korneliaaigner efficacyofregionalchemotherapyapproachinperitonealmetastaticgastriccancer AT yogeshkumarvashist efficacyofregionalchemotherapyapproachinperitonealmetastaticgastriccancer AT emirselak efficacyofregionalchemotherapyapproachinperitonealmetastaticgastriccancer AT sabinegailhofer efficacyofregionalchemotherapyapproachinperitonealmetastaticgastriccancer AT karlreinhardaigner efficacyofregionalchemotherapyapproachinperitonealmetastaticgastriccancer
_version_	1718411757907607552

Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer

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