Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering

Renu Geetha Bai,1 Kasturi Muthoosamy,1 Sivakumar Manickam,1 Ali Hilal-Alnaqbi21Nanotechnology and Advanced Materials (NATAM), Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, 43500, Malaysia; 2Electromechanical Technology, Abu Dhabi Polytechnic, Abu Dhabi, U...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Geetha Bai R, Muthoosamy K, Manickam S, Hilal-Alnaqbi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Graphene 3D tissue engineering scaffold microenvironment stem cells liver regenerative therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8f60ad9be69643de98a723d1238158a6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f60ad9be69643de98a723d1238158a6
record_format	dspace
spelling	oai:doaj.org-article:8f60ad9be69643de98a723d1238158a62021-12-02T00:01:46ZGraphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering1178-2013https://doaj.org/article/8f60ad9be69643de98a723d1238158a62019-07-01T00:00:00Zhttps://www.dovepress.com/graphene-based-3d-scaffolds-in-tissue-engineering-fabrication-applicat-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Renu Geetha Bai,1 Kasturi Muthoosamy,1 Sivakumar Manickam,1 Ali Hilal-Alnaqbi21Nanotechnology and Advanced Materials (NATAM), Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, 43500, Malaysia; 2Electromechanical Technology, Abu Dhabi Polytechnic, Abu Dhabi, United Arab EmiratesAbstract: Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy.Keywords: graphene, 3D, tissue engineering, scaffold, microenvironment, stem cells, liver, regenerative therapyGeetha Bai RMuthoosamy KManickam SHilal-Alnaqbi ADove Medical PressarticleGraphene3Dtissue engineeringscaffoldmicroenvironmentstem cellsliverregenerative therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5753-5783 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Graphene 3D tissue engineering scaffold microenvironment stem cells liver regenerative therapy Medicine (General) R5-920
spellingShingle	Graphene 3D tissue engineering scaffold microenvironment stem cells liver regenerative therapy Medicine (General) R5-920 Geetha Bai R Muthoosamy K Manickam S Hilal-Alnaqbi A Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
description	Renu Geetha Bai,1 Kasturi Muthoosamy,1 Sivakumar Manickam,1 Ali Hilal-Alnaqbi21Nanotechnology and Advanced Materials (NATAM), Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, 43500, Malaysia; 2Electromechanical Technology, Abu Dhabi Polytechnic, Abu Dhabi, United Arab EmiratesAbstract: Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy.Keywords: graphene, 3D, tissue engineering, scaffold, microenvironment, stem cells, liver, regenerative therapy
format	article
author	Geetha Bai R Muthoosamy K Manickam S Hilal-Alnaqbi A
author_facet	Geetha Bai R Muthoosamy K Manickam S Hilal-Alnaqbi A
author_sort	Geetha Bai R
title	Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_short	Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_full	Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_fullStr	Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_full_unstemmed	Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_sort	graphene-based 3d scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8f60ad9be69643de98a723d1238158a6
work_keys_str_mv	AT geethabair graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering AT muthoosamyk graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering AT manickams graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering AT hilalalnaqbia graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering
_version_	1718403998447304704

Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering

Ejemplares similares