Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease

Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease

Wei Li,1,2 Tao Wang,1,2 Shifu Xiao1,2 1Alzheimer’s Disease and Related Disorders Center, 2Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China Background: Mild cognitive impairme...

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Autores principales: Li W, Wang T, Xiao S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
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Keywords: type 2 diabetes mellitus
AD
MCI
cognition
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/8f6392824a454288844414eb02ef422a
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spelling oai:doaj.org-article:8f6392824a454288844414eb02ef422a2021-12-02T04:26:17ZType 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease1178-2021https://doaj.org/article/8f6392824a454288844414eb02ef422a2016-09-01T00:00:00Zhttps://www.dovepress.com/type-2-diabetes-mellitus-might-be-a-risk-factor-for-mild-cognitive-imp-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wei Li,1,2 Tao Wang,1,2 Shifu Xiao1,2 1Alzheimer’s Disease and Related Disorders Center, 2Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China Background: Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s disease (AD), so identification of the related risk factors can be helpful. Although the association between type 2 diabetes mellitus (T2DM) and these modest changes in cognition is well established, whether T2DM will promote the transformation of MCI into AD is not a unified conclusion.Objective: This study aims to explore the relationship between T2DM and MCI in the elderly population living in the community in Shanghai, People’s Republic of China.Methods: A total of 197 participants were included in the study. They were screened for T2DM, hyperlipidemia, traumatic brain injury, and family history of dementia. The Mini-Mental State Examination and the Montreal Cognitive Assessment were used to assess cognitive function. The diagnosis of AD was made according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, whereas the diagnosis of MCI was made according to Petersen’s criteria. Then, we investigated the relation between T2DM and MCI.Results: A total of 82 (41.6%) participants had no cognitive impairment, 82 (41.6%) participants had MCI, and 33 (16.8%) participants had AD. Multivariate logistic regression models demonstrated that T2DM was a risk factor for AD (odds ratio =49.723, 95% CI =21.173–111.987).Conclusion: T2DM might be a risk factor for MCI progressing into AD. Keywords: T2DM, AD, MCI, risk factorLi WWang TXiao SDove Medical PressarticleKeywords: type 2 diabetes mellitusADMCIcognitionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2489-2495 (2016)
institution DOAJ
collection DOAJ
language EN
topic Keywords: type 2 diabetes mellitus
AD
MCI
cognition
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Keywords: type 2 diabetes mellitus
AD
MCI
cognition
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Li W
Wang T
Xiao S
Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
description Wei Li,1,2 Tao Wang,1,2 Shifu Xiao1,2 1Alzheimer’s Disease and Related Disorders Center, 2Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China Background: Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s disease (AD), so identification of the related risk factors can be helpful. Although the association between type 2 diabetes mellitus (T2DM) and these modest changes in cognition is well established, whether T2DM will promote the transformation of MCI into AD is not a unified conclusion.Objective: This study aims to explore the relationship between T2DM and MCI in the elderly population living in the community in Shanghai, People’s Republic of China.Methods: A total of 197 participants were included in the study. They were screened for T2DM, hyperlipidemia, traumatic brain injury, and family history of dementia. The Mini-Mental State Examination and the Montreal Cognitive Assessment were used to assess cognitive function. The diagnosis of AD was made according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, whereas the diagnosis of MCI was made according to Petersen’s criteria. Then, we investigated the relation between T2DM and MCI.Results: A total of 82 (41.6%) participants had no cognitive impairment, 82 (41.6%) participants had MCI, and 33 (16.8%) participants had AD. Multivariate logistic regression models demonstrated that T2DM was a risk factor for AD (odds ratio =49.723, 95% CI =21.173–111.987).Conclusion: T2DM might be a risk factor for MCI progressing into AD. Keywords: T2DM, AD, MCI, risk factor
format article
author Li W
Wang T
Xiao S
author_facet Li W
Wang T
Xiao S
author_sort Li W
title Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
title_short Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
title_full Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
title_fullStr Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
title_full_unstemmed Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer’s disease
title_sort type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to alzheimer’s disease
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/8f6392824a454288844414eb02ef422a
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AT wangt type2diabetesmellitusmightbeariskfactorformildcognitiveimpairmentprogressingtoalzheimerrsquosdisease
AT xiaos type2diabetesmellitusmightbeariskfactorformildcognitiveimpairmentprogressingtoalzheimerrsquosdisease
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