The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery

Background: Whether perioperative packed red blood cell (pRBC) transfusion is associated with inferior long-term outcomes after stomach cancer surgery remains controversial. Methods: This research used a retrospective cohort study. Patients with stage I~III stomach cancer undergoing tumor resection...

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Autores principales:	Fu-Kai Hsu, Wen-Kuei Chang, Kuan-Ju Lin, Chun-Yu Liu, Wen-Liang Fang, Kuang-Yi Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blood transfusion disease-free survival dose-response survival analysis stomach neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8f67ef1f7b024fad8d57262a7acdccff
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spelling	oai:doaj.org-article:8f67ef1f7b024fad8d57262a7acdccff2021-11-11T15:31:41ZThe Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery10.3390/cancers132154382072-6694https://doaj.org/article/8f67ef1f7b024fad8d57262a7acdccff2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5438https://doaj.org/toc/2072-6694Background: Whether perioperative packed red blood cell (pRBC) transfusion is associated with inferior long-term outcomes after stomach cancer surgery remains controversial. Methods: This research used a retrospective cohort study. Patients with stage I~III stomach cancer undergoing tumor resection were collected at a tertiary medical center. Patient characteristics, surgical features and pathologic findings were gathered from an electronic medical chart review. The associations of perioperative pRBC transfusion with postoperative disease-free and overall survivals were evaluated using Cox regression analysis with an inverse probability of treatment weighting (IPTW). Restricted cubic spline functions were employed to characterize dose-response relationships between the amount of transfusion and cancer outcomes after surgery. Results: Among the 569 patients, 160 (28.1%) received perioperative pRBC transfusion. Perioperative transfusion was associated with worse disease-free survival (IPTW adjusted HR: 1.42, 95% CI: 1.18–1.71, <i>p</i> < 0.001) and overall survival (IPTW adjusted HR: 1.27, 95% CI: 1.05–1.55, <i>p</i> = 0.014). A non-linear dose-response relationship was noted between the amount of transfusions and worse disease-free or overall survival. Conclusions: Perioperative pRBC transfusion was associated with worse disease-free and overall survival after stomach cancer surgery, and strategies aiming to minimize perioperative transfusion exposure should be further considered to reduce the potential risk.Fu-Kai HsuWen-Kuei ChangKuan-Ju LinChun-Yu LiuWen-Liang FangKuang-Yi ChangMDPI AGarticleblood transfusiondisease-free survivaldose-responsesurvival analysisstomach neoplasmsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5438, p 5438 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood transfusion disease-free survival dose-response survival analysis stomach neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	blood transfusion disease-free survival dose-response survival analysis stomach neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fu-Kai Hsu Wen-Kuei Chang Kuan-Ju Lin Chun-Yu Liu Wen-Liang Fang Kuang-Yi Chang The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
description	Background: Whether perioperative packed red blood cell (pRBC) transfusion is associated with inferior long-term outcomes after stomach cancer surgery remains controversial. Methods: This research used a retrospective cohort study. Patients with stage I~III stomach cancer undergoing tumor resection were collected at a tertiary medical center. Patient characteristics, surgical features and pathologic findings were gathered from an electronic medical chart review. The associations of perioperative pRBC transfusion with postoperative disease-free and overall survivals were evaluated using Cox regression analysis with an inverse probability of treatment weighting (IPTW). Restricted cubic spline functions were employed to characterize dose-response relationships between the amount of transfusion and cancer outcomes after surgery. Results: Among the 569 patients, 160 (28.1%) received perioperative pRBC transfusion. Perioperative transfusion was associated with worse disease-free survival (IPTW adjusted HR: 1.42, 95% CI: 1.18–1.71, <i>p</i> < 0.001) and overall survival (IPTW adjusted HR: 1.27, 95% CI: 1.05–1.55, <i>p</i> = 0.014). A non-linear dose-response relationship was noted between the amount of transfusions and worse disease-free or overall survival. Conclusions: Perioperative pRBC transfusion was associated with worse disease-free and overall survival after stomach cancer surgery, and strategies aiming to minimize perioperative transfusion exposure should be further considered to reduce the potential risk.
format	article
author	Fu-Kai Hsu Wen-Kuei Chang Kuan-Ju Lin Chun-Yu Liu Wen-Liang Fang Kuang-Yi Chang
author_facet	Fu-Kai Hsu Wen-Kuei Chang Kuan-Ju Lin Chun-Yu Liu Wen-Liang Fang Kuang-Yi Chang
author_sort	Fu-Kai Hsu
title	The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
title_short	The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
title_full	The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
title_fullStr	The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
title_full_unstemmed	The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
title_sort	associations between perioperative blood transfusion and long-term outcomes after stomach cancer surgery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f67ef1f7b024fad8d57262a7acdccff
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The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery

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