Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study

Abstract Disseminated intravascular coagulation (DIC) is a common life-threatening complication in critically ill patients. The diagnostic scoring systems of DIC enable a more prompt and accurate diagnosis of DIC, such as the International Society on Thrombosis and Haemostasis (ISTH), the Japanese A...

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Autores principales:	Yingying Wu, Lili Luo, Ting Niu, Yue Han, Ying Feng, Qiulan Ding, Ruibin Huang, Xiaohui Zhang, Jianming Feng, Ming Hou, Jun Peng, Yan Li, Yuhong Zhou, Lei Su, Linhua Yang, Zeping Zhou, Feng Xue, Jian Gu, Tienan Zhu, Xiaomin Wang, Jun Deng, Heng Mei, Yu Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f685439c35f4c84805ad7286c37b546
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spelling	oai:doaj.org-article:8f685439c35f4c84805ad7286c37b5462021-12-02T12:32:08ZEvaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study10.1038/s41598-017-09190-52045-2322https://doaj.org/article/8f685439c35f4c84805ad7286c37b5462017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09190-5https://doaj.org/toc/2045-2322Abstract Disseminated intravascular coagulation (DIC) is a common life-threatening complication in critically ill patients. The diagnostic scoring systems of DIC enable a more prompt and accurate diagnosis of DIC, such as the International Society on Thrombosis and Haemostasis (ISTH), the Japanese Association for Acute Medicine (JAAM) and the Japanese Ministry of Health and Welfare (JMHW). This study prospectively evaluated the newly proposed Chinese DIC Scoring System (CDSS), which was conducted at 18 centers in China during a one-year period. Receiver operating characteristic (ROC) curves showed that, for diagnosis of DIC and for prediction of the 28-day all-cause mortality, the CDSS had larger areas under the ROC curve (AUCs) than the ISTH and the JAAM in different groups. The CDSS also had larger AUC than the JMHW for the ISTH DIC in non-infectious diseases. All of the AUCs of the CDSS were greater than 0.8, accompanied with both high sensitivity and high specificity. Furthermore, the CDSS score was an independent predictor of mortality (odds ratio, 1.882; p < 0.001), and could reflect the illness severity (p < 0.001 for Spearman’s rank correlations with the scores of severity). In conclusion, the CDSS is worthy of promotion with a better diagnostic and prognostic value for DIC.Yingying WuLili LuoTing NiuYue HanYing FengQiulan DingRuibin HuangXiaohui ZhangJianming FengMing HouJun PengYan LiYuhong ZhouLei SuLinhua YangZeping ZhouFeng XueJian GuTienan ZhuXiaomin WangJun DengHeng MeiYu HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yingying Wu Lili Luo Ting Niu Yue Han Ying Feng Qiulan Ding Ruibin Huang Xiaohui Zhang Jianming Feng Ming Hou Jun Peng Yan Li Yuhong Zhou Lei Su Linhua Yang Zeping Zhou Feng Xue Jian Gu Tienan Zhu Xiaomin Wang Jun Deng Heng Mei Yu Hu Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
description	Abstract Disseminated intravascular coagulation (DIC) is a common life-threatening complication in critically ill patients. The diagnostic scoring systems of DIC enable a more prompt and accurate diagnosis of DIC, such as the International Society on Thrombosis and Haemostasis (ISTH), the Japanese Association for Acute Medicine (JAAM) and the Japanese Ministry of Health and Welfare (JMHW). This study prospectively evaluated the newly proposed Chinese DIC Scoring System (CDSS), which was conducted at 18 centers in China during a one-year period. Receiver operating characteristic (ROC) curves showed that, for diagnosis of DIC and for prediction of the 28-day all-cause mortality, the CDSS had larger areas under the ROC curve (AUCs) than the ISTH and the JAAM in different groups. The CDSS also had larger AUC than the JMHW for the ISTH DIC in non-infectious diseases. All of the AUCs of the CDSS were greater than 0.8, accompanied with both high sensitivity and high specificity. Furthermore, the CDSS score was an independent predictor of mortality (odds ratio, 1.882; p < 0.001), and could reflect the illness severity (p < 0.001 for Spearman’s rank correlations with the scores of severity). In conclusion, the CDSS is worthy of promotion with a better diagnostic and prognostic value for DIC.
format	article
author	Yingying Wu Lili Luo Ting Niu Yue Han Ying Feng Qiulan Ding Ruibin Huang Xiaohui Zhang Jianming Feng Ming Hou Jun Peng Yan Li Yuhong Zhou Lei Su Linhua Yang Zeping Zhou Feng Xue Jian Gu Tienan Zhu Xiaomin Wang Jun Deng Heng Mei Yu Hu
author_facet	Yingying Wu Lili Luo Ting Niu Yue Han Ying Feng Qiulan Ding Ruibin Huang Xiaohui Zhang Jianming Feng Ming Hou Jun Peng Yan Li Yuhong Zhou Lei Su Linhua Yang Zeping Zhou Feng Xue Jian Gu Tienan Zhu Xiaomin Wang Jun Deng Heng Mei Yu Hu
author_sort	Yingying Wu
title	Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
title_short	Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
title_full	Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
title_fullStr	Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
title_full_unstemmed	Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study
title_sort	evaluation of the new chinese disseminated intravascular coagulation scoring system in critically ill patients: a multicenter prospective study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8f685439c35f4c84805ad7286c37b546
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Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study

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