CtIP is required to initiate replication-dependent interstrand crosslink repair.

CtIP is required to initiate replication-dependent interstrand crosslink repair.

DNA interstrand crosslinks (ICLs) are toxic lesions that block the progression of replication and transcription. CtIP is a conserved DNA repair protein that facilitates DNA end resection in the double-strand break (DSB) repair pathway. Here we show that CtIP plays a critical role during initiation o...

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Autores principales: Michelle L Duquette, Qingyuan Zhu, Ewan R Taylor, Angela J Tsay, Linda Z Shi, Michael W Berns, Clare H McGowan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/8f6f239b578c43518c801b93d319f176
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