PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expr...

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Autores principales:	Feng Dong, Qian Li, Chao Yang, Dawei Huo, Xing Wang, Chunbo Ai, Yu Kong, Xiaoyu Sun, Wen Wang, Yan Zhou, Xing Liu, Wei Li, Weiwei Gao, Wen Liu, Chunsheng Kang, Xudong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f79abb72a05486c8ed09b9953768969
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spelling	oai:doaj.org-article:8f79abb72a05486c8ed09b99537689692021-12-02T15:33:37ZPRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma10.1038/s41467-018-06968-72041-1723https://doaj.org/article/8f79abb72a05486c8ed09b99537689692018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06968-7https://doaj.org/toc/2041-1723The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expression programs, at least partly dependent on its H3R8me2a activity, in GBM pathogenesis.Feng DongQian LiChao YangDawei HuoXing WangChunbo AiYu KongXiaoyu SunWen WangYan ZhouXing LiuWei LiWeiwei GaoWen LiuChunsheng KangXudong WuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Dong Qian Li Chao Yang Dawei Huo Xing Wang Chunbo Ai Yu Kong Xiaoyu Sun Wen Wang Yan Zhou Xing Liu Wei Li Weiwei Gao Wen Liu Chunsheng Kang Xudong Wu PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
description	The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expression programs, at least partly dependent on its H3R8me2a activity, in GBM pathogenesis.
format	article
author	Feng Dong Qian Li Chao Yang Dawei Huo Xing Wang Chunbo Ai Yu Kong Xiaoyu Sun Wen Wang Yan Zhou Xing Liu Wei Li Weiwei Gao Wen Liu Chunsheng Kang Xudong Wu
author_facet	Feng Dong Qian Li Chao Yang Dawei Huo Xing Wang Chunbo Ai Yu Kong Xiaoyu Sun Wen Wang Yan Zhou Xing Liu Wei Li Weiwei Gao Wen Liu Chunsheng Kang Xudong Wu
author_sort	Feng Dong
title	PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
title_short	PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
title_full	PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
title_fullStr	PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
title_full_unstemmed	PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
title_sort	prmt2 links histone h3r8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8f79abb72a05486c8ed09b9953768969
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PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

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