Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.

Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the im...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elsa Vera, Bruno Bernardes de Jesus, Miguel Foronda, Juana M Flores, Maria A Blasco
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f7fba8dd6f641bfa6c085b5d64d3f8d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f7fba8dd6f641bfa6c085b5d64d3f8d
record_format	dspace
spelling	oai:doaj.org-article:8f7fba8dd6f641bfa6c085b5d64d3f8d2021-11-18T08:00:40ZTelomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.1932-620310.1371/journal.pone.0053760https://doaj.org/article/8f7fba8dd6f641bfa6c085b5d64d3f8d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23349740/?tool=EBIhttps://doaj.org/toc/1932-6203Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts. These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing "health span" and extending mouse longevity.Elsa VeraBruno Bernardes de JesusMiguel ForondaJuana M FloresMaria A BlascoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53760 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elsa Vera Bruno Bernardes de Jesus Miguel Foronda Juana M Flores Maria A Blasco Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
description	Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts. These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing "health span" and extending mouse longevity.
format	article
author	Elsa Vera Bruno Bernardes de Jesus Miguel Foronda Juana M Flores Maria A Blasco
author_facet	Elsa Vera Bruno Bernardes de Jesus Miguel Foronda Juana M Flores Maria A Blasco
author_sort	Elsa Vera
title	Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
title_short	Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
title_full	Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
title_fullStr	Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
title_full_unstemmed	Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
title_sort	telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8f7fba8dd6f641bfa6c085b5d64d3f8d
work_keys_str_mv	AT elsavera telomerasereversetranscriptasesynergizeswithcalorierestrictiontoincreasehealthspanandextendmouselongevity AT brunobernardesdejesus telomerasereversetranscriptasesynergizeswithcalorierestrictiontoincreasehealthspanandextendmouselongevity AT miguelforonda telomerasereversetranscriptasesynergizeswithcalorierestrictiontoincreasehealthspanandextendmouselongevity AT juanamflores telomerasereversetranscriptasesynergizeswithcalorierestrictiontoincreasehealthspanandextendmouselongevity AT mariaablasco telomerasereversetranscriptasesynergizeswithcalorierestrictiontoincreasehealthspanandextendmouselongevity
_version_	1718422681176506368

Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.

Ejemplares similares