Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.

<h4>Objective</h4>This study aimed external validation of a formerly developed prediction model identifying children at risk for hearing loss after bacterial meningitis (BM). Independent risk factors included in the model are: duration of symptoms prior to admission, petechiae, cerebral...

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Autores principales: Rogier C J de Jonge, Marieke S Sanders, Caroline B Terwee, Martijn W Heymans, Reinoud J B J Gemke, Irene Koomen, Lodewijk Spanjaard, A Marceline van Furth
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:8f81656c8130499583b142528286a1b92021-11-18T07:53:57ZIndependent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.1932-620310.1371/journal.pone.0058707https://doaj.org/article/8f81656c8130499583b142528286a1b92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23536814/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed external validation of a formerly developed prediction model identifying children at risk for hearing loss after bacterial meningitis (BM). Independent risk factors included in the model are: duration of symptoms prior to admission, petechiae, cerebral spinal fluid (CSF) glucose level, Streptococcus pneumoniae and ataxia. Validation helps to evaluate whether the model has potential in clinical practice.<h4>Study design</h4>116 Dutch school-age BM survivors were included in the validation cohort and screened for sensorineural hearing loss (>25 dB). Risk factors were obtained from medical records. The model was applied to the validation cohort and its performance was compared with the development cohort. Validation was performed by application of the model on the validation cohort and by assessment of discrimination and goodness of fit. Calibration was evaluated by testing deviations in intercept and slope. Multiple imputation techniques were used to deal with missing values.<h4>Results</h4>Risk factors were distributed equally between both cohorts. Discriminative ability (Area Under the Curve, AUC) of the model was 0.84 in the development and 0.78 in the validation cohort. Hosmer-Lemeshow test for goodness of fit was not significant in the validation cohort, implying good fit concerning the similarity of expected and observed cases. There were no significant differences in calibration slope and intercept. Sensitivity and negative predicted value were high, while specificity and positive predicted value were low which is comparable with findings in the development cohort.<h4>Conclusions</h4>Performance of the model remained good in the validation cohort. This prediction model might be used as a screening tool and can help to identify those children that need special attention and a long follow-up period or more frequent auditory testing.Rogier C J de JongeMarieke S SandersCaroline B TerweeMartijn W HeymansReinoud J B J GemkeIrene KoomenLodewijk SpanjaardA Marceline van FurthPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58707 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rogier C J de Jonge
Marieke S Sanders
Caroline B Terwee
Martijn W Heymans
Reinoud J B J Gemke
Irene Koomen
Lodewijk Spanjaard
A Marceline van Furth
Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
description <h4>Objective</h4>This study aimed external validation of a formerly developed prediction model identifying children at risk for hearing loss after bacterial meningitis (BM). Independent risk factors included in the model are: duration of symptoms prior to admission, petechiae, cerebral spinal fluid (CSF) glucose level, Streptococcus pneumoniae and ataxia. Validation helps to evaluate whether the model has potential in clinical practice.<h4>Study design</h4>116 Dutch school-age BM survivors were included in the validation cohort and screened for sensorineural hearing loss (>25 dB). Risk factors were obtained from medical records. The model was applied to the validation cohort and its performance was compared with the development cohort. Validation was performed by application of the model on the validation cohort and by assessment of discrimination and goodness of fit. Calibration was evaluated by testing deviations in intercept and slope. Multiple imputation techniques were used to deal with missing values.<h4>Results</h4>Risk factors were distributed equally between both cohorts. Discriminative ability (Area Under the Curve, AUC) of the model was 0.84 in the development and 0.78 in the validation cohort. Hosmer-Lemeshow test for goodness of fit was not significant in the validation cohort, implying good fit concerning the similarity of expected and observed cases. There were no significant differences in calibration slope and intercept. Sensitivity and negative predicted value were high, while specificity and positive predicted value were low which is comparable with findings in the development cohort.<h4>Conclusions</h4>Performance of the model remained good in the validation cohort. This prediction model might be used as a screening tool and can help to identify those children that need special attention and a long follow-up period or more frequent auditory testing.
format article
author Rogier C J de Jonge
Marieke S Sanders
Caroline B Terwee
Martijn W Heymans
Reinoud J B J Gemke
Irene Koomen
Lodewijk Spanjaard
A Marceline van Furth
author_facet Rogier C J de Jonge
Marieke S Sanders
Caroline B Terwee
Martijn W Heymans
Reinoud J B J Gemke
Irene Koomen
Lodewijk Spanjaard
A Marceline van Furth
author_sort Rogier C J de Jonge
title Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
title_short Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
title_full Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
title_fullStr Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
title_full_unstemmed Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
title_sort independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/8f81656c8130499583b142528286a1b9
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