Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast

The first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. The receptors for bitter and sweet taste, may, apparently, have opposite functions, but in available literature there is no data on the balance of sensitivity fo...

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Autores principales:	V. N. Mineev, M. A. Nyoma, L. N. Sorokina, P. V. Bryukhanova, D. E. Koksharova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	bronchial asthma gustometry taste receptors bitter taste sweet taste Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8f84b34f1a464b11a8a5467f5c50e35c
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spelling	oai:doaj.org-article:8f84b34f1a464b11a8a5467f5c50e35c2021-11-18T08:03:50ZGustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast1563-06252313-741X10.15789/1563-0625-GIV-2070https://doaj.org/article/8f84b34f1a464b11a8a5467f5c50e35c2021-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2070https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. The receptors for bitter and sweet taste, may, apparently, have opposite functions, but in available literature there is no data on the balance of sensitivity for bitter and sweet tastes in the same patients with bronchial asthma. The aim of the present work is to simultaneously assess the sensitivity of canonical lingual receptors to bitter and sweet taste in the same patients with different clinical variants of bronchial asthma by methods applicable in wide clinical practice. 16 healthy persons and 35 patients with bronchial asthma were examined at the M.V. Chernorutsky Clinics of Hospital Therapy at First St. Petersburg State I. Pavlov Medical University. The sensitivity for bitter taste was assessed using The Frey Scientific 569885 PTC Taste Paper test strip kit containing phenylthiourea solution. Sucrose solutions at concentrations of 0.3; 0,4; 0,5; 0,6; 0,7; 0,8; 0,9 % for determination of individual value of taste thresholds to sweet taste were used. The bitter-to-sweet taste sensitivity balance was assessed on the basis of an original “bitter/sweet taste sensitivity” index. The highest values of index of bitter/sweet taste was found in the allergic variant of bronchial asthma: its values are significantly different from those in healthy persons only at low sucrose concentrations (0.3-0.4%). The factor analysis revealed an association between taste imbalance (a shift towards high sensitivity to sweet taste) and key characteristics of bronchial asthma, including severity of bronchial asthma course, duration of inhaled glucocorticosteroid use and inefficiency of β2-agonists use at pre-clinical stage. It has been revealed by gustometry that in the allergic variant of bronchial asthma there is a decreased sensitivity for bitter test substance (phenylthiourea), along with higher sensitivity for sweet taste (sucrose).V. N. MineevM. A. NyomaL. N. SorokinaP. V. BryukhanovaD. E. KoksharovaSPb RAACIarticlebronchial asthmagustometrytaste receptorsbitter tastesweet tasteImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 1, Pp 117-126 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma gustometry taste receptors bitter taste sweet taste Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma gustometry taste receptors bitter taste sweet taste Immunologic diseases. Allergy RC581-607 V. N. Mineev M. A. Nyoma L. N. Sorokina P. V. Bryukhanova D. E. Koksharova Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
description	The first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. The receptors for bitter and sweet taste, may, apparently, have opposite functions, but in available literature there is no data on the balance of sensitivity for bitter and sweet tastes in the same patients with bronchial asthma. The aim of the present work is to simultaneously assess the sensitivity of canonical lingual receptors to bitter and sweet taste in the same patients with different clinical variants of bronchial asthma by methods applicable in wide clinical practice. 16 healthy persons and 35 patients with bronchial asthma were examined at the M.V. Chernorutsky Clinics of Hospital Therapy at First St. Petersburg State I. Pavlov Medical University. The sensitivity for bitter taste was assessed using The Frey Scientific 569885 PTC Taste Paper test strip kit containing phenylthiourea solution. Sucrose solutions at concentrations of 0.3; 0,4; 0,5; 0,6; 0,7; 0,8; 0,9 % for determination of individual value of taste thresholds to sweet taste were used. The bitter-to-sweet taste sensitivity balance was assessed on the basis of an original “bitter/sweet taste sensitivity” index. The highest values of index of bitter/sweet taste was found in the allergic variant of bronchial asthma: its values are significantly different from those in healthy persons only at low sucrose concentrations (0.3-0.4%). The factor analysis revealed an association between taste imbalance (a shift towards high sensitivity to sweet taste) and key characteristics of bronchial asthma, including severity of bronchial asthma course, duration of inhaled glucocorticosteroid use and inefficiency of β2-agonists use at pre-clinical stage. It has been revealed by gustometry that in the allergic variant of bronchial asthma there is a decreased sensitivity for bitter test substance (phenylthiourea), along with higher sensitivity for sweet taste (sucrose).
format	article
author	V. N. Mineev M. A. Nyoma L. N. Sorokina P. V. Bryukhanova D. E. Koksharova
author_facet	V. N. Mineev M. A. Nyoma L. N. Sorokina P. V. Bryukhanova D. E. Koksharova
author_sort	V. N. Mineev
title	Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
title_short	Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
title_full	Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
title_fullStr	Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
title_full_unstemmed	Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
title_sort	gustometry in various variants of bronchial asthma: sensitivity thresholds for bitter and sweet tast
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/8f84b34f1a464b11a8a5467f5c50e35c
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Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast

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