Training/detraining-induced gender specific functional adaptations of isolated rat heart

Background/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac a...

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Autores principales:	Dragojlović-Ružičić Radica, Radovanović Dragan, Milanović Zvezdan, Petković Anica, Jeremić Jovana, Nikolić-Тurnić Tamara, Milosavljević Isidora, Srejović Ivan, Živković Vladimir, Krivokuća Živko, Jakovljević Vladimir, Đorđević Dušica
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	adaptation, physiological exercise rats heart gender Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8f84c8443de545b59f41fefec78ac600
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spelling	oai:doaj.org-article:8f84c8443de545b59f41fefec78ac6002021-12-01T13:00:25ZTraining/detraining-induced gender specific functional adaptations of isolated rat heart0042-84502406-072010.2298/VSP191127027Dhttps://doaj.org/article/8f84c8443de545b59f41fefec78ac6002021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000027D.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac adaptation reversibility after the cessation of aerobic exercise and to reveal gender differences in achieved effects of training/detraining. Methods. Fe-male and male Wistar albino rats were divided into the following groups: control, trained, and two detrained groups. Hearts were perfused according to the Langendorff technique and the following cardiodynamic parameters were determined: the maximum and minimum rate of pressure development in the left ventricle (dp/dt max and dp/dt min, respectively), systolic and diastolic left ventricular pressure (SLVP and DLVP, respectively), heart rate (HR), and coronary flow. Results. Training significantly reduced values of dp/dt max, dp/dt min, and SLVP in males and females, and coronary flow in males. Detraining caused a reversion of those changes, which was gender-specific. In females, levels of SLVP were higher after 4 weeks of detraining compred to training, and after 2 weeks of detraining. Values of SLVP were lower in both detraining periods compared to training in males. Males had higher coronary flow after 2 weeks of detraining. Simultaneously, coronary flow was reduced in the 4th week of detraining in females. Conclusion. By using a model of the isolated rat heart, the present study confirmed the existence of training-induced changes in cardiac function. Cessation of training was followed by the loss of those adaptations, faster in males than females.Dragojlović-Ružičić RadicaRadovanović DraganMilanović ZvezdanPetković AnicaJeremić JovanaNikolić-Тurnić TamaraMilosavljević IsidoraSrejović IvanŽivković VladimirKrivokuća ŽivkoJakovljević VladimirĐorđević DušicaMilitary Health Department, Ministry of Defance, Serbiaarticleadaptation, physiologicalexerciseratsheartgenderMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 11, Pp 1146-1154 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	adaptation, physiological exercise rats heart gender Medicine (General) R5-920
spellingShingle	adaptation, physiological exercise rats heart gender Medicine (General) R5-920 Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica Training/detraining-induced gender specific functional adaptations of isolated rat heart
description	Background/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac adaptation reversibility after the cessation of aerobic exercise and to reveal gender differences in achieved effects of training/detraining. Methods. Fe-male and male Wistar albino rats were divided into the following groups: control, trained, and two detrained groups. Hearts were perfused according to the Langendorff technique and the following cardiodynamic parameters were determined: the maximum and minimum rate of pressure development in the left ventricle (dp/dt max and dp/dt min, respectively), systolic and diastolic left ventricular pressure (SLVP and DLVP, respectively), heart rate (HR), and coronary flow. Results. Training significantly reduced values of dp/dt max, dp/dt min, and SLVP in males and females, and coronary flow in males. Detraining caused a reversion of those changes, which was gender-specific. In females, levels of SLVP were higher after 4 weeks of detraining compred to training, and after 2 weeks of detraining. Values of SLVP were lower in both detraining periods compared to training in males. Males had higher coronary flow after 2 weeks of detraining. Simultaneously, coronary flow was reduced in the 4th week of detraining in females. Conclusion. By using a model of the isolated rat heart, the present study confirmed the existence of training-induced changes in cardiac function. Cessation of training was followed by the loss of those adaptations, faster in males than females.
format	article
author	Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica
author_facet	Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica
author_sort	Dragojlović-Ružičić Radica
title	Training/detraining-induced gender specific functional adaptations of isolated rat heart
title_short	Training/detraining-induced gender specific functional adaptations of isolated rat heart
title_full	Training/detraining-induced gender specific functional adaptations of isolated rat heart
title_fullStr	Training/detraining-induced gender specific functional adaptations of isolated rat heart
title_full_unstemmed	Training/detraining-induced gender specific functional adaptations of isolated rat heart
title_sort	training/detraining-induced gender specific functional adaptations of isolated rat heart
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/8f84c8443de545b59f41fefec78ac600
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Training/detraining-induced gender specific functional adaptations of isolated rat heart

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