Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan

Abstract Background Anemia and electrolyte disturbances are adverse outcomes of chronic kidney disease (CKD). This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders among CKD patients in Taiwan. Methods This cross-sectional study with a tot...

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Autores principales:	Adi Lukas Kurniawan, Ya-Lan Yang, Chien-Yeh Hsu, Rathi Paramastri, Hsiu-An Lee, Po-Yuan Ni, Mei-Yun Chin, Jane C.-J. Chao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anemia Electrolyte disturbances Mineral disorders Chronic kidney disease Metabolic parameters Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/8f8f2759f19648969b04023c5b12d47b
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spelling	oai:doaj.org-article:8f8f2759f19648969b04023c5b12d47b2021-11-21T12:42:28ZAssociation between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan10.1186/s12882-021-02590-w1471-2369https://doaj.org/article/8f8f2759f19648969b04023c5b12d47b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02590-whttps://doaj.org/toc/1471-2369Abstract Background Anemia and electrolyte disturbances are adverse outcomes of chronic kidney disease (CKD). This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders among CKD patients in Taiwan. Methods This cross-sectional study with a total of 2176 CKD stages 3–5 patients were collected from the Department of Nephrology at Shuang Ho Hospital, Taipei Medical University through the “Chronic Kidney Disease Common Care Network” database from December 2008 to April 2019. A multivariable-adjusted logistic regression expressed as odd ratios (OR) was performed to assess the association of metabolic parameters with anemia and electrolyte and mineral disorders. Results Elevated diastolic blood pressure, fasting blood glucose, and glycated hemoglobin A1c (HbA1c) were associated with presence of anemia. Similarly, elevated fasting blood glucose and HbA1c were associated with hyponatremia (OR = 1.59 and 1.58, P for both < 0.01) and hypercalcemia (OR = 1.38 and 1.33, P for both < 0.05). There was no significant association in serum lipid levels with presence of anemia. However, total triglycerides, total cholesterol and low-density lipoprotein-cholesterol were only associated with presence of hypercalcemia (OR = 1.43, 1.95 and 3.08, respectively, P for all < 0.05). Conclusions Elevated diastolic blood pressure, fasting blood glucose, HbA1c and blood lipids are associated with anemia or electrolyte and mineral disorders in CKD patients.Adi Lukas KurniawanYa-Lan YangChien-Yeh HsuRathi ParamastriHsiu-An LeePo-Yuan NiMei-Yun ChinJane C.-J. ChaoBMCarticleAnemiaElectrolyte disturbancesMineral disordersChronic kidney diseaseMetabolic parametersDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anemia Electrolyte disturbances Mineral disorders Chronic kidney disease Metabolic parameters Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Anemia Electrolyte disturbances Mineral disorders Chronic kidney disease Metabolic parameters Diseases of the genitourinary system. Urology RC870-923 Adi Lukas Kurniawan Ya-Lan Yang Chien-Yeh Hsu Rathi Paramastri Hsiu-An Lee Po-Yuan Ni Mei-Yun Chin Jane C.-J. Chao Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
description	Abstract Background Anemia and electrolyte disturbances are adverse outcomes of chronic kidney disease (CKD). This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders among CKD patients in Taiwan. Methods This cross-sectional study with a total of 2176 CKD stages 3–5 patients were collected from the Department of Nephrology at Shuang Ho Hospital, Taipei Medical University through the “Chronic Kidney Disease Common Care Network” database from December 2008 to April 2019. A multivariable-adjusted logistic regression expressed as odd ratios (OR) was performed to assess the association of metabolic parameters with anemia and electrolyte and mineral disorders. Results Elevated diastolic blood pressure, fasting blood glucose, and glycated hemoglobin A1c (HbA1c) were associated with presence of anemia. Similarly, elevated fasting blood glucose and HbA1c were associated with hyponatremia (OR = 1.59 and 1.58, P for both < 0.01) and hypercalcemia (OR = 1.38 and 1.33, P for both < 0.05). There was no significant association in serum lipid levels with presence of anemia. However, total triglycerides, total cholesterol and low-density lipoprotein-cholesterol were only associated with presence of hypercalcemia (OR = 1.43, 1.95 and 3.08, respectively, P for all < 0.05). Conclusions Elevated diastolic blood pressure, fasting blood glucose, HbA1c and blood lipids are associated with anemia or electrolyte and mineral disorders in CKD patients.
format	article
author	Adi Lukas Kurniawan Ya-Lan Yang Chien-Yeh Hsu Rathi Paramastri Hsiu-An Lee Po-Yuan Ni Mei-Yun Chin Jane C.-J. Chao
author_facet	Adi Lukas Kurniawan Ya-Lan Yang Chien-Yeh Hsu Rathi Paramastri Hsiu-An Lee Po-Yuan Ni Mei-Yun Chin Jane C.-J. Chao
author_sort	Adi Lukas Kurniawan
title	Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
title_short	Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
title_full	Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
title_fullStr	Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
title_full_unstemmed	Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
title_sort	association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in taiwan
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8f8f2759f19648969b04023c5b12d47b
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Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan

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