Impairment of intermediate somatosensory function in corticobasal syndrome

Abstract Corticobasal syndrome (CBS) is characterized by unilateral atrophy of the brain. New diagnostic criteria for CBS include intermediate somatosensory dysfunction. Here, we aimed to carefully examine intermediate somatosensory function to identify tests which can assess impairment in CBS patie...

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Autores principales:	Kana Matsuda, Masayuki Satoh, Ken-ichi Tabei, Yukito Ueda, Akira Taniguchi, Keita Matsuura, Masaru Asahi, Yuichiro Ii, Atsushi Niwa, Hidekazu Tomimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f9038ac83fb4ead8b48874faf6575d7
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spelling	oai:doaj.org-article:8f9038ac83fb4ead8b48874faf6575d72021-12-02T15:39:48ZImpairment of intermediate somatosensory function in corticobasal syndrome10.1038/s41598-020-67991-72045-2322https://doaj.org/article/8f9038ac83fb4ead8b48874faf6575d72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67991-7https://doaj.org/toc/2045-2322Abstract Corticobasal syndrome (CBS) is characterized by unilateral atrophy of the brain. New diagnostic criteria for CBS include intermediate somatosensory dysfunction. Here, we aimed to carefully examine intermediate somatosensory function to identify tests which can assess impairment in CBS patients. Using voxel-based morphometry (VBM), we also aimed to show the anatomical bases of these impairments. Subjects included 14 patients diagnosed with CBS and 14 patients with Parkinson's disease (PD). Patients were evaluated using intermediate somatosensory tests and neuropsychological assessments. VBM was used to analyze differences in gray matter volumes between CBS and PD patients. In the PD group, no tests showed a significant difference between the dominant-side onset and the non-dominant-side onset. In the CBS group, all tests showed worse scores on the affected side. For detecting intermediate somatosensory dysfunction in CBS, two tests are recommended: tactile object naming and 2-point discrimination. VBM analysis showed that the volume of the left post- and pre-central gyrus, and both sides of the supplementary motor area were significantly decreased in the CBS group compared to the PD group. Although CBS remains untreatable, early and correct diagnosis is possible by performing close examination of intermediate somatosensory function.Kana MatsudaMasayuki SatohKen-ichi TabeiYukito UedaAkira TaniguchiKeita MatsuuraMasaru AsahiYuichiro IiAtsushi NiwaHidekazu TomimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kana Matsuda Masayuki Satoh Ken-ichi Tabei Yukito Ueda Akira Taniguchi Keita Matsuura Masaru Asahi Yuichiro Ii Atsushi Niwa Hidekazu Tomimoto Impairment of intermediate somatosensory function in corticobasal syndrome
description	Abstract Corticobasal syndrome (CBS) is characterized by unilateral atrophy of the brain. New diagnostic criteria for CBS include intermediate somatosensory dysfunction. Here, we aimed to carefully examine intermediate somatosensory function to identify tests which can assess impairment in CBS patients. Using voxel-based morphometry (VBM), we also aimed to show the anatomical bases of these impairments. Subjects included 14 patients diagnosed with CBS and 14 patients with Parkinson's disease (PD). Patients were evaluated using intermediate somatosensory tests and neuropsychological assessments. VBM was used to analyze differences in gray matter volumes between CBS and PD patients. In the PD group, no tests showed a significant difference between the dominant-side onset and the non-dominant-side onset. In the CBS group, all tests showed worse scores on the affected side. For detecting intermediate somatosensory dysfunction in CBS, two tests are recommended: tactile object naming and 2-point discrimination. VBM analysis showed that the volume of the left post- and pre-central gyrus, and both sides of the supplementary motor area were significantly decreased in the CBS group compared to the PD group. Although CBS remains untreatable, early and correct diagnosis is possible by performing close examination of intermediate somatosensory function.
format	article
author	Kana Matsuda Masayuki Satoh Ken-ichi Tabei Yukito Ueda Akira Taniguchi Keita Matsuura Masaru Asahi Yuichiro Ii Atsushi Niwa Hidekazu Tomimoto
author_facet	Kana Matsuda Masayuki Satoh Ken-ichi Tabei Yukito Ueda Akira Taniguchi Keita Matsuura Masaru Asahi Yuichiro Ii Atsushi Niwa Hidekazu Tomimoto
author_sort	Kana Matsuda
title	Impairment of intermediate somatosensory function in corticobasal syndrome
title_short	Impairment of intermediate somatosensory function in corticobasal syndrome
title_full	Impairment of intermediate somatosensory function in corticobasal syndrome
title_fullStr	Impairment of intermediate somatosensory function in corticobasal syndrome
title_full_unstemmed	Impairment of intermediate somatosensory function in corticobasal syndrome
title_sort	impairment of intermediate somatosensory function in corticobasal syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8f9038ac83fb4ead8b48874faf6575d7
work_keys_str_mv	AT kanamatsuda impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT masayukisatoh impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT kenichitabei impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT yukitoueda impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT akirataniguchi impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT keitamatsuura impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT masaruasahi impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT yuichiroii impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT atsushiniwa impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome AT hidekazutomimoto impairmentofintermediatesomatosensoryfunctionincorticobasalsyndrome
_version_	1718385885993500672

Impairment of intermediate somatosensory function in corticobasal syndrome

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