Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine

Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent complications of diabetes. Of all the symptoms associa...

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Autores principales:	Russell J, Zilliox L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Duloxetine Diabetic Neuropathy Neuropathic Pain Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8f92c0e58ace4076ae320594867d9837
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spelling	oai:doaj.org-article:8f92c0e58ace4076ae320594867d98372021-12-02T02:45:10ZMaintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine1178-7007https://doaj.org/article/8f92c0e58ace4076ae320594867d98372010-01-01T00:00:00Zhttps://www.dovepress.com/maintaining-efficacy-in-the-treatment-of-diabetic-peripheral-neuropath-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent complications of diabetes. Of all the symptoms associated with diabetic neuropathy, pain has the largest impact on sleep and quality of life. In the past few years further medications have been added to the available therapies for neuropathic pain. One of these medications, duloxetine hydrochloride (duloxetine), is a balanced and potent selective serotonin and norepinephrine reuptake inhibitor.Methods: Medline was searched from January 2005 to September 2009 using the key words duloxetine and peripheral neuropathy for clinical trials limited to human research published in English and duloxetine and pharmacology in the nervous system.Results: Duloxetine has been shown to effectively reduce diabetic peripheral neuropathic pain compared to placebo at doses of 60 mg/day and 120 mg/day with minimal to moderate side effects. This effect is seen with minimal effects on glycemic control and without any clinically relevant effects on lipid control, or cardiovascular parameters. In addition, its efficacy and tolerability is comparable to other medications commonly used in the management of neuropathic pain. Furthermore, duloxetine performs favorably both in terms of quality of life and in cost utility analyses.Discussion and conclusion: This article reviewed the issues related to management of diabetic peripheral neuropathic pain, the pharmacology and rationale for use of duloxetine, efficacy studies, and the safety and tolerability of treatment with duloxetine. Duloxetine is an acceptable initial or alternative treatment for patients with diabetic neuropathic pain.Keywords: duloxetine, diabetic neuropathy, neuropathic painRussell JZilliox LDove Medical PressarticleDuloxetineDiabetic NeuropathyNeuropathic PainSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 7-17 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Duloxetine Diabetic Neuropathy Neuropathic Pain Specialties of internal medicine RC581-951
spellingShingle	Duloxetine Diabetic Neuropathy Neuropathic Pain Specialties of internal medicine RC581-951 Russell J Zilliox L Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
description	Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent complications of diabetes. Of all the symptoms associated with diabetic neuropathy, pain has the largest impact on sleep and quality of life. In the past few years further medications have been added to the available therapies for neuropathic pain. One of these medications, duloxetine hydrochloride (duloxetine), is a balanced and potent selective serotonin and norepinephrine reuptake inhibitor.Methods: Medline was searched from January 2005 to September 2009 using the key words duloxetine and peripheral neuropathy for clinical trials limited to human research published in English and duloxetine and pharmacology in the nervous system.Results: Duloxetine has been shown to effectively reduce diabetic peripheral neuropathic pain compared to placebo at doses of 60 mg/day and 120 mg/day with minimal to moderate side effects. This effect is seen with minimal effects on glycemic control and without any clinically relevant effects on lipid control, or cardiovascular parameters. In addition, its efficacy and tolerability is comparable to other medications commonly used in the management of neuropathic pain. Furthermore, duloxetine performs favorably both in terms of quality of life and in cost utility analyses.Discussion and conclusion: This article reviewed the issues related to management of diabetic peripheral neuropathic pain, the pharmacology and rationale for use of duloxetine, efficacy studies, and the safety and tolerability of treatment with duloxetine. Duloxetine is an acceptable initial or alternative treatment for patients with diabetic neuropathic pain.Keywords: duloxetine, diabetic neuropathy, neuropathic pain
format	article
author	Russell J Zilliox L
author_facet	Russell J Zilliox L
author_sort	Russell J
title	Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
title_short	Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
title_full	Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
title_fullStr	Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
title_full_unstemmed	Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
title_sort	maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/8f92c0e58ace4076ae320594867d9837
work_keys_str_mv	AT russellj maintainingefficacyinthetreatmentofdiabeticperipheralneuropathicpainroleofduloxetine AT zillioxl maintainingefficacyinthetreatmentofdiabeticperipheralneuropathicpainroleofduloxetine
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Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine

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