Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells.
<h4>Background</h4>Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2009
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8f9323f3746541df9de934bf541c36aa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8f9323f3746541df9de934bf541c36aa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8f9323f3746541df9de934bf541c36aa2021-11-25T06:28:36ZConverting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells.1932-620310.1371/journal.pone.0007538https://doaj.org/article/8f9323f3746541df9de934bf541c36aa2009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19844581/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.<h4>Methodology/principal findings</h4>We here report a systematic detection of transcriptome changes in response to oxidative signals generated in leukemia cells upon fenretinide treatment, implicating the occurrence of numerous stress-responsive events during the fenretinide induced apoptosis, such as redox response, endoplasmic reticulum stress/unfolded protein response, translational repression and proteasome activation. Moreover, the configuration of these relevant events is primarily orchestrated by stress responsive transcription factors, as typically highlighted by NF-E2-related factor-2 (NRF2) and heat shock factor 1 (HSF1). Several lines of evidence suggest that the coordinated regulation of these transcription factors and thus their downstream genes are involved in converting oxidative signaling into downstream stress-responsive events regulating pro-apoptotic and apoptotic activities at the temporal and spatial levels, typifying oxidative stress-mediated programmed death rather than survival in cancer cells.<h4>Conclusions/significance</h4>This study provides a roadmap for understanding oxidative stress-mediated apoptosis in cancer cells, which may be further developed into more sophisticated therapeutic protocols, as implicated by synergistic induction of cell apoptosis using proteasome inhibitors with fenretinide.Kankan WangHai FangDakai XiaoXuehua ZhuMiaomiao HeXiaoling PanJiantao ShiHui ZhangXiaohong JiaYanzhi DuJi ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 10, p e7538 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Kankan Wang Hai Fang Dakai Xiao Xuehua Zhu Miaomiao He Xiaoling Pan Jiantao Shi Hui Zhang Xiaohong Jia Yanzhi Du Ji Zhang Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| description |
<h4>Background</h4>Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.<h4>Methodology/principal findings</h4>We here report a systematic detection of transcriptome changes in response to oxidative signals generated in leukemia cells upon fenretinide treatment, implicating the occurrence of numerous stress-responsive events during the fenretinide induced apoptosis, such as redox response, endoplasmic reticulum stress/unfolded protein response, translational repression and proteasome activation. Moreover, the configuration of these relevant events is primarily orchestrated by stress responsive transcription factors, as typically highlighted by NF-E2-related factor-2 (NRF2) and heat shock factor 1 (HSF1). Several lines of evidence suggest that the coordinated regulation of these transcription factors and thus their downstream genes are involved in converting oxidative signaling into downstream stress-responsive events regulating pro-apoptotic and apoptotic activities at the temporal and spatial levels, typifying oxidative stress-mediated programmed death rather than survival in cancer cells.<h4>Conclusions/significance</h4>This study provides a roadmap for understanding oxidative stress-mediated apoptosis in cancer cells, which may be further developed into more sophisticated therapeutic protocols, as implicated by synergistic induction of cell apoptosis using proteasome inhibitors with fenretinide. |
| format |
article |
| author |
Kankan Wang Hai Fang Dakai Xiao Xuehua Zhu Miaomiao He Xiaoling Pan Jiantao Shi Hui Zhang Xiaohong Jia Yanzhi Du Ji Zhang |
| author_facet |
Kankan Wang Hai Fang Dakai Xiao Xuehua Zhu Miaomiao He Xiaoling Pan Jiantao Shi Hui Zhang Xiaohong Jia Yanzhi Du Ji Zhang |
| author_sort |
Kankan Wang |
| title |
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| title_short |
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| title_full |
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| title_fullStr |
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| title_full_unstemmed |
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. |
| title_sort |
converting redox signaling to apoptotic activities by stress-responsive regulators hsf1 and nrf2 in fenretinide treated cancer cells. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/8f9323f3746541df9de934bf541c36aa |
| work_keys_str_mv |
AT kankanwang convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT haifang convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT dakaixiao convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT xuehuazhu convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT miaomiaohe convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT xiaolingpan convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT jiantaoshi convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT huizhang convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT xiaohongjia convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT yanzhidu convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells AT jizhang convertingredoxsignalingtoapoptoticactivitiesbystressresponsiveregulatorshsf1andnrf2infenretinidetreatedcancercells |
| _version_ |
1718413693758210048 |