The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus

Changwu Tan,1– 3,* Xiaoqiang Wang,4,* Yuchang Wang,1– 3 Chuansen Wang,1– 3 Zhi Tang,5 Zhiping Zhang,1– 3 Jingping Liu,1– 3 Gelei Xiao1– 3 1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, Peopl...

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Autores principales:	Tan C, Wang X, Wang Y, Wang C, Tang Z, Zhang Z, Liu J, Xiao G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	idiopathic normal pressure hydrocephalus glymphatic system pathogenesis diagnostic methods shunt surgery. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8f93d75748b94ba4b26307a0b2d05330
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spelling	oai:doaj.org-article:8f93d75748b94ba4b26307a0b2d053302021-12-02T15:19:13ZThe Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus1178-1998https://doaj.org/article/8f93d75748b94ba4b26307a0b2d053302021-01-01T00:00:00Zhttps://www.dovepress.com/the-pathogenesis-based-on-the-glymphatic-system-diagnosis-and-treatmen-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Changwu Tan,1– 3,* Xiaoqiang Wang,4,* Yuchang Wang,1– 3 Chuansen Wang,1– 3 Zhi Tang,5 Zhiping Zhang,1– 3 Jingping Liu,1– 3 Gelei Xiao1– 3 1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 2Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 4Pediatric Neurological Disease Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, People’s Republic of China; 5Department of Neurosurgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gelei XiaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaTel +8613707314060Email xiaogelei@csu.edu.cnAbstract: Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder with no clear prevalence factors and is a significant danger to the elderly. The intracranial glymphatic system is the internal environment that maintains brain survival and metabolism, and thus fluid exchange changes in the glymphatic system under various pathological conditions can provide important insights into the pathogenesis and differential diagnosis of many neurodegenerative diseases such as iNPH. iNPH can be diagnosed using a combination of clinical symptoms, imaging findings and history, and cerebrospinal fluid biomarkers due to the glymphatic system disorder. However, only few researchers have linked the two. Shunt surgery can improve the glymphatic system disorders in iNPH patients, and the surgical approach is determined using a combination of clinical diagnosis and trials. Therefore, we have composed this review to provide a future opportunity for elucidating the pathogenesis of iNPH based on the glymphatic system, and link the glymphatic system to the diagnosis and treatment of iNPH. The review will provide new insights into the medical research of iNPH.Keywords: idiopathic normal pressure hydrocephalus, glymphatic system, pathogenesis, diagnostic methods, shunt surgeryTan CWang XWang YWang CTang ZZhang ZLiu JXiao GDove Medical Pressarticleidiopathic normal pressure hydrocephalusglymphatic systempathogenesisdiagnostic methodsshunt surgery.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 139-153 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic normal pressure hydrocephalus glymphatic system pathogenesis diagnostic methods shunt surgery. Geriatrics RC952-954.6
spellingShingle	idiopathic normal pressure hydrocephalus glymphatic system pathogenesis diagnostic methods shunt surgery. Geriatrics RC952-954.6 Tan C Wang X Wang Y Wang C Tang Z Zhang Z Liu J Xiao G The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
description	Changwu Tan,1– 3,* Xiaoqiang Wang,4,* Yuchang Wang,1– 3 Chuansen Wang,1– 3 Zhi Tang,5 Zhiping Zhang,1– 3 Jingping Liu,1– 3 Gelei Xiao1– 3 1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 2Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China; 4Pediatric Neurological Disease Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, People’s Republic of China; 5Department of Neurosurgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gelei XiaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaTel +8613707314060Email xiaogelei@csu.edu.cnAbstract: Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder with no clear prevalence factors and is a significant danger to the elderly. The intracranial glymphatic system is the internal environment that maintains brain survival and metabolism, and thus fluid exchange changes in the glymphatic system under various pathological conditions can provide important insights into the pathogenesis and differential diagnosis of many neurodegenerative diseases such as iNPH. iNPH can be diagnosed using a combination of clinical symptoms, imaging findings and history, and cerebrospinal fluid biomarkers due to the glymphatic system disorder. However, only few researchers have linked the two. Shunt surgery can improve the glymphatic system disorders in iNPH patients, and the surgical approach is determined using a combination of clinical diagnosis and trials. Therefore, we have composed this review to provide a future opportunity for elucidating the pathogenesis of iNPH based on the glymphatic system, and link the glymphatic system to the diagnosis and treatment of iNPH. The review will provide new insights into the medical research of iNPH.Keywords: idiopathic normal pressure hydrocephalus, glymphatic system, pathogenesis, diagnostic methods, shunt surgery
format	article
author	Tan C Wang X Wang Y Wang C Tang Z Zhang Z Liu J Xiao G
author_facet	Tan C Wang X Wang Y Wang C Tang Z Zhang Z Liu J Xiao G
author_sort	Tan C
title	The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
title_short	The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
title_full	The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
title_fullStr	The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
title_full_unstemmed	The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
title_sort	pathogenesis based on the glymphatic system, diagnosis, and treatment of idiopathic normal pressure hydrocephalus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8f93d75748b94ba4b26307a0b2d05330
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The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus

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