Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.

Maternal licking and grooming (LG) exerts profound influence on hippocampal development and function in the offspring. However, little information is available on the effects of variations in maternal care on other brain regions. Here we examined the effects of variation in the frequency of maternal...

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Autores principales:	Laura A Smit-Rigter, Danielle L Champagne, Johannes A van Hooft
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f9843f608a74594a30b8c35c429516f
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spelling	oai:doaj.org-article:8f9843f608a74594a30b8c35c429516f2021-11-25T06:16:12ZLifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.1932-620310.1371/journal.pone.0005167https://doaj.org/article/8f9843f608a74594a30b8c35c429516f2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19357777/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Maternal licking and grooming (LG) exerts profound influence on hippocampal development and function in the offspring. However, little information is available on the effects of variations in maternal care on other brain regions. Here we examined the effects of variation in the frequency of maternal LG on morphological and electrophysiological properties of layer 2/3 pyramidal neurons in the somatosensory cortex in adult offspring. Compared to low LG offspring, high LG offspring displayed decreased dendritic complexity, reduced spine density and decreased amplitude of spontaneous postsynaptic currents. These changes were accompanied by higher levels of reelin expression in offspring of high LG mothers. Taken together, these findings suggest that differential amount of naturally-occurring variations in maternal LG is associated with enduring changes in dendritic morphology and synaptic function in layer 2/3 pyramidal neurons of the somatosensory cortex.Laura A Smit-RigterDanielle L ChampagneJohannes A van HooftPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 4, p e5167 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura A Smit-Rigter Danielle L Champagne Johannes A van Hooft Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
description	Maternal licking and grooming (LG) exerts profound influence on hippocampal development and function in the offspring. However, little information is available on the effects of variations in maternal care on other brain regions. Here we examined the effects of variation in the frequency of maternal LG on morphological and electrophysiological properties of layer 2/3 pyramidal neurons in the somatosensory cortex in adult offspring. Compared to low LG offspring, high LG offspring displayed decreased dendritic complexity, reduced spine density and decreased amplitude of spontaneous postsynaptic currents. These changes were accompanied by higher levels of reelin expression in offspring of high LG mothers. Taken together, these findings suggest that differential amount of naturally-occurring variations in maternal LG is associated with enduring changes in dendritic morphology and synaptic function in layer 2/3 pyramidal neurons of the somatosensory cortex.
format	article
author	Laura A Smit-Rigter Danielle L Champagne Johannes A van Hooft
author_facet	Laura A Smit-Rigter Danielle L Champagne Johannes A van Hooft
author_sort	Laura A Smit-Rigter
title	Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
title_short	Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
title_full	Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
title_fullStr	Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
title_full_unstemmed	Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
title_sort	lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/8f9843f608a74594a30b8c35c429516f
work_keys_str_mv	AT lauraasmitrigter lifelongimpactofvariationsinmaternalcareondendriticstructureandfunctionofcorticallayer23pyramidalneuronsinratoffspring AT daniellelchampagne lifelongimpactofvariationsinmaternalcareondendriticstructureandfunctionofcorticallayer23pyramidalneuronsinratoffspring AT johannesavanhooft lifelongimpactofvariationsinmaternalcareondendriticstructureandfunctionofcorticallayer23pyramidalneuronsinratoffspring
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Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring.

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