Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review

Congenital adrenal hyperplasia (CAH) refers to group of inherited diseases resulting from impaired adrenal steroidogenesis, and its most common cause is 21-hydroxylase deficiency. Testicular adrenal rest tumors (TARTs) are an important complication of CAH, which probably develop from ectopic remnant...

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Autores principales:	Hiba Hassan Ali, Alaa Samkari, Haitham Arabi
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2013
Materias:	leydig cell tumor testicular adrenal rest tumor testicular mass Medicine R
Acceso en línea:	https://doaj.org/article/8f9b9c82f8d34227b83caedba882c641
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spelling	oai:doaj.org-article:8f9b9c82f8d34227b83caedba882c6412021-12-02T17:59:10ZTesticular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review2231-07702249-446410.4103/2231-0770.112789https://doaj.org/article/8f9b9c82f8d34227b83caedba882c6412013-01-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.112789https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Congenital adrenal hyperplasia (CAH) refers to group of inherited diseases resulting from impaired adrenal steroidogenesis, and its most common cause is 21-hydroxylase deficiency. Testicular adrenal rest tumors (TARTs) are an important complication of CAH, which probably develop from ectopic remnants of intra-testicular adrenal tissue stimulated by Adrenocorticotropic hormone (ACTH) hypersecretion. These lesions are typically located within the rete testis and are bilateral, synchronous, nodular and multiple. TART usually, but not always, responses to suppressive medical therapy. TART leads to testicular structural damage, spermatogenesis disorders, infertility and most importantly, mass-forming lesions that could be mistaken for Leydig cell tumor (LCT). The later has a significantly different behavior with up to 10% of being malignant. Nowadays, due to advances in diagnosing and treating CAH, mass-forming TART is rarely encountered. As a result, there is the paucity in the medical literature regarding its features from pathological perspective. We herein present a case of mass-forming TART and we discuss the clinical, radiological, and morphological features as well as the major differential diagnosis of this rare lesion.Hiba Hassan AliAlaa SamkariHaitham ArabiThieme Medical and Scientific Publishers Pvt. Ltd.articleleydig cell tumortesticular adrenal rest tumortesticular massMedicineRENAvicenna Journal of Medicine, Vol 03, Iss 01, Pp 15-19 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	leydig cell tumor testicular adrenal rest tumor testicular mass Medicine R
spellingShingle	leydig cell tumor testicular adrenal rest tumor testicular mass Medicine R Hiba Hassan Ali Alaa Samkari Haitham Arabi Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
description	Congenital adrenal hyperplasia (CAH) refers to group of inherited diseases resulting from impaired adrenal steroidogenesis, and its most common cause is 21-hydroxylase deficiency. Testicular adrenal rest tumors (TARTs) are an important complication of CAH, which probably develop from ectopic remnants of intra-testicular adrenal tissue stimulated by Adrenocorticotropic hormone (ACTH) hypersecretion. These lesions are typically located within the rete testis and are bilateral, synchronous, nodular and multiple. TART usually, but not always, responses to suppressive medical therapy. TART leads to testicular structural damage, spermatogenesis disorders, infertility and most importantly, mass-forming lesions that could be mistaken for Leydig cell tumor (LCT). The later has a significantly different behavior with up to 10% of being malignant. Nowadays, due to advances in diagnosing and treating CAH, mass-forming TART is rarely encountered. As a result, there is the paucity in the medical literature regarding its features from pathological perspective. We herein present a case of mass-forming TART and we discuss the clinical, radiological, and morphological features as well as the major differential diagnosis of this rare lesion.
format	article
author	Hiba Hassan Ali Alaa Samkari Haitham Arabi
author_facet	Hiba Hassan Ali Alaa Samkari Haitham Arabi
author_sort	Hiba Hassan Ali
title	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
title_short	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
title_full	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
title_fullStr	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
title_full_unstemmed	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review
title_sort	testicular adrenal rest "tumor" or leydig cell tumor? a report of a challenging case with literature review
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2013
url	https://doaj.org/article/8f9b9c82f8d34227b83caedba882c641
work_keys_str_mv	AT hibahassanali testicularadrenalresttumororleydigcelltumorareportofachallengingcasewithliteraturereview AT alaasamkari testicularadrenalresttumororleydigcelltumorareportofachallengingcasewithliteraturereview AT haithamarabi testicularadrenalresttumororleydigcelltumorareportofachallengingcasewithliteraturereview
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Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review

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