Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

In the field of 18F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective 18F-labeling of biomolecules. Am...

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Autores principales:	Sandip S. Shinde, Simone Maschauer, Olaf Prante
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fluorine-18 prosthetic group <sup>18</sup>F-fluoroglycosylation positron emission tomography PET Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8f9d379a10724a7bad6cf05af0b0f11d
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spelling	oai:doaj.org-article:8f9d379a10724a7bad6cf05af0b0f11d2021-11-25T18:39:56ZSweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects10.3390/ph141111751424-8247https://doaj.org/article/8f9d379a10724a7bad6cf05af0b0f11d2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1175https://doaj.org/toc/1424-8247In the field of <sup>18</sup>F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective <sup>18</sup>F-labeling of biomolecules. Among those, chemoselective <sup>18</sup>F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of <sup>18</sup>F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various <sup>18</sup>F-fluoroglycosylation methods that were developed and applied as of 2014 (Maschauer and Prante, BioMed. Res. Int. 2014, 214748). This paper is an updated review, providing the recent progress in <sup>18</sup>F-fluoroglycosylation reactions and the preclinical application of <sup>18</sup>F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins.Sandip S. ShindeSimone MaschauerOlaf PranteMDPI AGarticlefluorine-18prosthetic group<sup>18</sup>F-fluoroglycosylationpositron emission tomographyPETMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1175, p 1175 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fluorine-18 prosthetic group <sup>18</sup>F-fluoroglycosylation positron emission tomography PET Medicine R Pharmacy and materia medica RS1-441
spellingShingle	fluorine-18 prosthetic group <sup>18</sup>F-fluoroglycosylation positron emission tomography PET Medicine R Pharmacy and materia medica RS1-441 Sandip S. Shinde Simone Maschauer Olaf Prante Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
description	In the field of <sup>18</sup>F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective <sup>18</sup>F-labeling of biomolecules. Among those, chemoselective <sup>18</sup>F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of <sup>18</sup>F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various <sup>18</sup>F-fluoroglycosylation methods that were developed and applied as of 2014 (Maschauer and Prante, BioMed. Res. Int. 2014, 214748). This paper is an updated review, providing the recent progress in <sup>18</sup>F-fluoroglycosylation reactions and the preclinical application of <sup>18</sup>F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins.
format	article
author	Sandip S. Shinde Simone Maschauer Olaf Prante
author_facet	Sandip S. Shinde Simone Maschauer Olaf Prante
author_sort	Sandip S. Shinde
title	Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
title_short	Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
title_full	Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
title_fullStr	Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
title_full_unstemmed	Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects
title_sort	sweetening pharmaceutical radiochemistry by <sup>18</sup>f-fluoroglycosylation: recent progress and future prospects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f9d379a10724a7bad6cf05af0b0f11d
work_keys_str_mv	AT sandipsshinde sweeteningpharmaceuticalradiochemistrybysup18supffluoroglycosylationrecentprogressandfutureprospects AT simonemaschauer sweeteningpharmaceuticalradiochemistrybysup18supffluoroglycosylationrecentprogressandfutureprospects AT olafprante sweeteningpharmaceuticalradiochemistrybysup18supffluoroglycosylationrecentprogressandfutureprospects
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Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects

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