Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men

Shang-Rong Zhong,1 Han-Hsuan Yang,1– 3 Cheng-Hsi Liao,4– 7 Deng-Ho Yang,5,6,8,9 Shih-Kai Tu,1,5 Chia-Lien Hung,6 Chun-Cheng Liao1,5,6 1Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; 2Department of Occupational Medicine, Taichung Veterans...

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Autores principales:	Zhong SR, Yang HH, Liao CH, Yang DH, Tu SK, Hung CL, Liao CC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	testosterone metabolic syndrome hypogonadism insulin resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8f9de9f99b664aa1a02ad5cef692f64b
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spelling	oai:doaj.org-article:8f9de9f99b664aa1a02ad5cef692f64b2021-12-02T14:01:50ZAssociation Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men1178-7007https://doaj.org/article/8f9de9f99b664aa1a02ad5cef692f64b2021-01-01T00:00:00Zhttps://www.dovepress.com/association-between-low-serum-testosterone-and-the-development-of-meta-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shang-Rong Zhong,1 Han-Hsuan Yang,1– 3 Cheng-Hsi Liao,4– 7 Deng-Ho Yang,5,6,8,9 Shih-Kai Tu,1,5 Chia-Lien Hung,6 Chun-Cheng Liao1,5,6 1Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; 2Department of Occupational Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 3School of Professional Education and Continuing Studies, National Taiwan University, Taipei, Taiwan; 4Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan; 5School of Medicine, National Defense Medical Center, Taipei, Taiwan; 6Department of Medical Education and Research, Taichung Armed Forces General Hospital, Taichung, Taiwan; 7Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; 8Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; 9Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, TaiwanCorrespondence: Chun-Cheng Liao Email milkbottle97@yahoo.com.twPurpose: To assess the association between serum testosterone (T) and metabolic syndrome (MS) in different age groups in Taiwanese men.Materials and Methods: Male participants, regardless of age or any underlying disease, were identified from MJ Health Screening Center in Taiwan from 2007 to 2016 for this cross-sectional study. They were divided into three groups according to age, and further classified according to MS diagnosis. Basic patient characteristics with relevant parameters were obtained. One-way ANOVA of mean T values between different numbers of measures that exceeds the cut-off values of MS components was performed to assess the relationship of T and MS. Logistic regression analysis was also used to estimate the risk for MS with each increment in T, age, and BMI.Results: A total of 4,931 men were included. The MS group had significantly lower serum T levels compared to the non-MS group in each age group. The one-way ANOVA found the mean value of T was significantly higher in patients without MS component (6.19± 2.12 ng/mL) than those with 1– 5 MS components (with one MS component: 5.48± 2.13 ng/mL, two MS components: 4.93± 2.03 ng/mL, three MS components: 4.37± 1.60 ng/mL, four MS components: 4.13± 2.89 ng/mL, five MS components: 3.74± 1.27 ng/mL, and P< 0.001). There was no significant difference between the patients with three components and the patients with four or five components. Logistic regression models with age stratification showed T with lower odds ratio (OR) for MS after adjusting for BMI in those ≥ 65 years old (OR=0.693; 95% CI=0.559– 0.858; P< 0.001); 50– 64 years old (OR=0.868; 95% CI=0.802– 0.940; P< 0.001) and < 50 years old (OR=0.810; 95% CI=0.758– 0.865; P< 0.001).Conclusion: Lower serum T was strongly associated with MS, with the predictive value increasing with age in Taiwanese men.Keywords: testosterone, metabolic syndrome, hypogonadism, insulin resistanceZhong SRYang HHLiao CHYang DHTu SKHung CLLiao CCDove Medical Pressarticletestosteronemetabolic syndromehypogonadisminsulin resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 99-106 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	testosterone metabolic syndrome hypogonadism insulin resistance Specialties of internal medicine RC581-951
spellingShingle	testosterone metabolic syndrome hypogonadism insulin resistance Specialties of internal medicine RC581-951 Zhong SR Yang HH Liao CH Yang DH Tu SK Hung CL Liao CC Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
description	Shang-Rong Zhong,1 Han-Hsuan Yang,1– 3 Cheng-Hsi Liao,4– 7 Deng-Ho Yang,5,6,8,9 Shih-Kai Tu,1,5 Chia-Lien Hung,6 Chun-Cheng Liao1,5,6 1Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; 2Department of Occupational Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 3School of Professional Education and Continuing Studies, National Taiwan University, Taipei, Taiwan; 4Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan; 5School of Medicine, National Defense Medical Center, Taipei, Taiwan; 6Department of Medical Education and Research, Taichung Armed Forces General Hospital, Taichung, Taiwan; 7Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; 8Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; 9Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, TaiwanCorrespondence: Chun-Cheng Liao Email milkbottle97@yahoo.com.twPurpose: To assess the association between serum testosterone (T) and metabolic syndrome (MS) in different age groups in Taiwanese men.Materials and Methods: Male participants, regardless of age or any underlying disease, were identified from MJ Health Screening Center in Taiwan from 2007 to 2016 for this cross-sectional study. They were divided into three groups according to age, and further classified according to MS diagnosis. Basic patient characteristics with relevant parameters were obtained. One-way ANOVA of mean T values between different numbers of measures that exceeds the cut-off values of MS components was performed to assess the relationship of T and MS. Logistic regression analysis was also used to estimate the risk for MS with each increment in T, age, and BMI.Results: A total of 4,931 men were included. The MS group had significantly lower serum T levels compared to the non-MS group in each age group. The one-way ANOVA found the mean value of T was significantly higher in patients without MS component (6.19± 2.12 ng/mL) than those with 1– 5 MS components (with one MS component: 5.48± 2.13 ng/mL, two MS components: 4.93± 2.03 ng/mL, three MS components: 4.37± 1.60 ng/mL, four MS components: 4.13± 2.89 ng/mL, five MS components: 3.74± 1.27 ng/mL, and P< 0.001). There was no significant difference between the patients with three components and the patients with four or five components. Logistic regression models with age stratification showed T with lower odds ratio (OR) for MS after adjusting for BMI in those ≥ 65 years old (OR=0.693; 95% CI=0.559– 0.858; P< 0.001); 50– 64 years old (OR=0.868; 95% CI=0.802– 0.940; P< 0.001) and < 50 years old (OR=0.810; 95% CI=0.758– 0.865; P< 0.001).Conclusion: Lower serum T was strongly associated with MS, with the predictive value increasing with age in Taiwanese men.Keywords: testosterone, metabolic syndrome, hypogonadism, insulin resistance
format	article
author	Zhong SR Yang HH Liao CH Yang DH Tu SK Hung CL Liao CC
author_facet	Zhong SR Yang HH Liao CH Yang DH Tu SK Hung CL Liao CC
author_sort	Zhong SR
title	Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
title_short	Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
title_full	Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
title_fullStr	Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
title_full_unstemmed	Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men
title_sort	association between low serum testosterone and the development of metabolic syndrome in elderly taiwanese men
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8f9de9f99b664aa1a02ad5cef692f64b
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Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men

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