The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumul...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Julien Bricambert, Marie-Clotilde Alves-Guerra, Pauline Esteves, Carina Prip-Buus, Justine Bertrand-Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne-Hergaux, Philippe Mathurin, Violeta Raverdy, François Pattou, Jean Girard, Catherine Postic, Renaud Dentin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8f9e79eadea04b11aa096c85f31e9bb9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.

Ejemplares similares