The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumul...

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Autores principales: Julien Bricambert, Marie-Clotilde Alves-Guerra, Pauline Esteves, Carina Prip-Buus, Justine Bertrand-Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne-Hergaux, Philippe Mathurin, Violeta Raverdy, François Pattou, Jean Girard, Catherine Postic, Renaud Dentin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8f9e79eadea04b11aa096c85f31e9bb9
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spelling oai:doaj.org-article:8f9e79eadea04b11aa096c85f31e9bb92021-12-02T15:33:53ZThe histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity10.1038/s41467-018-04361-y2041-1723https://doaj.org/article/8f9e79eadea04b11aa096c85f31e9bb92018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04361-yhttps://doaj.org/toc/2041-1723Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.Julien BricambertMarie-Clotilde Alves-GuerraPauline EstevesCarina Prip-BuusJustine Bertrand-MichelHervé GuillouChristopher J. ChangMark N. Vander WalFrançois Canonne-HergauxPhilippe MathurinVioleta RaverdyFrançois PattouJean GirardCatherine PosticRenaud DentinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julien Bricambert
Marie-Clotilde Alves-Guerra
Pauline Esteves
Carina Prip-Buus
Justine Bertrand-Michel
Hervé Guillou
Christopher J. Chang
Mark N. Vander Wal
François Canonne-Hergaux
Philippe Mathurin
Violeta Raverdy
François Pattou
Jean Girard
Catherine Postic
Renaud Dentin
The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
description Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.
format article
author Julien Bricambert
Marie-Clotilde Alves-Guerra
Pauline Esteves
Carina Prip-Buus
Justine Bertrand-Michel
Hervé Guillou
Christopher J. Chang
Mark N. Vander Wal
François Canonne-Hergaux
Philippe Mathurin
Violeta Raverdy
François Pattou
Jean Girard
Catherine Postic
Renaud Dentin
author_facet Julien Bricambert
Marie-Clotilde Alves-Guerra
Pauline Esteves
Carina Prip-Buus
Justine Bertrand-Michel
Hervé Guillou
Christopher J. Chang
Mark N. Vander Wal
François Canonne-Hergaux
Philippe Mathurin
Violeta Raverdy
François Pattou
Jean Girard
Catherine Postic
Renaud Dentin
author_sort Julien Bricambert
title The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
title_short The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
title_full The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
title_fullStr The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
title_full_unstemmed The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
title_sort histone demethylase phf2 acts as a molecular checkpoint to prevent nafld progression during obesity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8f9e79eadea04b11aa096c85f31e9bb9
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