Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions

Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated TH9 cell differentiation, while p38 activation by PKC-β antagonizes this effect, thereby supporting a synergy between p38 inhib...

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Autores principales:	Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai, Jianli Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8fa021e49b09489b82dc2c0a56718b53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8fa021e49b09489b82dc2c0a56718b532021-12-02T15:35:34ZFas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions10.1038/s41467-019-10889-42041-1723https://doaj.org/article/8fa021e49b09489b82dc2c0a56718b532019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10889-4https://doaj.org/toc/2041-1723Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated TH9 cell differentiation, while p38 activation by PKC-β antagonizes this effect, thereby supporting a synergy between p38 inhibitor and Fas for TH9 differentiation.Yingying ShenZhengbo SongXinliang LuZeyu MaChaojie LuBei ZhangYinghu ChenMeng DuanLionel ApetohXu LiJufeng GuoYing MiaoGensheng ZhangDiya YangZhijian CaiJianli WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingying Shen Zhengbo Song Xinliang Lu Zeyu Ma Chaojie Lu Bei Zhang Yinghu Chen Meng Duan Lionel Apetoh Xu Li Jufeng Guo Ying Miao Gensheng Zhang Diya Yang Zhijian Cai Jianli Wang Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
description	Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated TH9 cell differentiation, while p38 activation by PKC-β antagonizes this effect, thereby supporting a synergy between p38 inhibitor and Fas for TH9 differentiation.
format	article
author	Yingying Shen Zhengbo Song Xinliang Lu Zeyu Ma Chaojie Lu Bei Zhang Yinghu Chen Meng Duan Lionel Apetoh Xu Li Jufeng Guo Ying Miao Gensheng Zhang Diya Yang Zhijian Cai Jianli Wang
author_facet	Yingying Shen Zhengbo Song Xinliang Lu Zeyu Ma Chaojie Lu Bei Zhang Yinghu Chen Meng Duan Lionel Apetoh Xu Li Jufeng Guo Ying Miao Gensheng Zhang Diya Yang Zhijian Cai Jianli Wang
author_sort	Yingying Shen
title	Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
title_short	Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
title_full	Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
title_fullStr	Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
title_full_unstemmed	Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
title_sort	fas signaling-mediated th9 cell differentiation favors bowel inflammation and antitumor functions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8fa021e49b09489b82dc2c0a56718b53
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Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions

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