Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analysis of the DRB1*15:01 allele with risk of leprosy i...

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Autores principales:	Ben Krause-Kyora, Marcel Nutsua, Lisa Boehme, Federica Pierini, Dorthe Dangvard Pedersen, Sabin-Christin Kornell, Dmitriy Drichel, Marion Bonazzi, Lena Möbus, Peter Tarp, Julian Susat, Esther Bosse, Beatrix Willburger, Alexander H. Schmidt, Jürgen Sauter, Andre Franke, Michael Wittig, Amke Caliebe, Michael Nothnagel, Stefan Schreiber, Jesper L. Boldsen, Tobias L. Lenz, Almut Nebel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8fa5ee6a3c694f099a3d3800433d8665
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spelling	oai:doaj.org-article:8fa5ee6a3c694f099a3d3800433d86652021-12-02T15:33:59ZAncient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans10.1038/s41467-018-03857-x2041-1723https://doaj.org/article/8fa5ee6a3c694f099a3d3800433d86652018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03857-xhttps://doaj.org/toc/2041-1723Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analysis of the DRB1*15:01 allele with risk of leprosy infection.Ben Krause-KyoraMarcel NutsuaLisa BoehmeFederica PieriniDorthe Dangvard PedersenSabin-Christin KornellDmitriy DrichelMarion BonazziLena MöbusPeter TarpJulian SusatEsther BosseBeatrix WillburgerAlexander H. SchmidtJürgen SauterAndre FrankeMichael WittigAmke CaliebeMichael NothnagelStefan SchreiberJesper L. BoldsenTobias L. LenzAlmut NebelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ben Krause-Kyora Marcel Nutsua Lisa Boehme Federica Pierini Dorthe Dangvard Pedersen Sabin-Christin Kornell Dmitriy Drichel Marion Bonazzi Lena Möbus Peter Tarp Julian Susat Esther Bosse Beatrix Willburger Alexander H. Schmidt Jürgen Sauter Andre Franke Michael Wittig Amke Caliebe Michael Nothnagel Stefan Schreiber Jesper L. Boldsen Tobias L. Lenz Almut Nebel Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
description	Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analysis of the DRB1*15:01 allele with risk of leprosy infection.
format	article
author	Ben Krause-Kyora Marcel Nutsua Lisa Boehme Federica Pierini Dorthe Dangvard Pedersen Sabin-Christin Kornell Dmitriy Drichel Marion Bonazzi Lena Möbus Peter Tarp Julian Susat Esther Bosse Beatrix Willburger Alexander H. Schmidt Jürgen Sauter Andre Franke Michael Wittig Amke Caliebe Michael Nothnagel Stefan Schreiber Jesper L. Boldsen Tobias L. Lenz Almut Nebel
author_facet	Ben Krause-Kyora Marcel Nutsua Lisa Boehme Federica Pierini Dorthe Dangvard Pedersen Sabin-Christin Kornell Dmitriy Drichel Marion Bonazzi Lena Möbus Peter Tarp Julian Susat Esther Bosse Beatrix Willburger Alexander H. Schmidt Jürgen Sauter Andre Franke Michael Wittig Amke Caliebe Michael Nothnagel Stefan Schreiber Jesper L. Boldsen Tobias L. Lenz Almut Nebel
author_sort	Ben Krause-Kyora
title	Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
title_short	Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
title_full	Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
title_fullStr	Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
title_full_unstemmed	Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
title_sort	ancient dna study reveals hla susceptibility locus for leprosy in medieval europeans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8fa5ee6a3c694f099a3d3800433d8665
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Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

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