Thermogenetic neurostimulation with single-cell resolution

Thermogenetic neurostimulation with single-cell resolution

Current approaches to thermogenetic manipulation of neuronal activity lack sufficient spatiotemporal resolution. Here the authors show that neurons expressing snake TRPA1 channels are activated at high temporal resolution with IR light and this technique can be used to elicit behaviour in zebrafish...

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Auteurs principaux: Yulia G. Ermakova, Aleksandr A. Lanin, Ilya V. Fedotov, Matvey Roshchin, Ilya V. Kelmanson, Dmitry Kulik, Yulia A. Bogdanova, Arina G. Shokhina, Dmitry S. Bilan, Dmitry B. Staroverov, Pavel M. Balaban, Andrei B. Fedotov, Dmitry A. Sidorov-Biryukov, Evgeny S. Nikitin, Aleksei M. Zheltikov, Vsevolod V. Belousov
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
Q
Accès en ligne:https://doaj.org/article/8fa5f9b23ffb42af95a59011913d928a
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Résumé:Current approaches to thermogenetic manipulation of neuronal activity lack sufficient spatiotemporal resolution. Here the authors show that neurons expressing snake TRPA1 channels are activated at high temporal resolution with IR light and this technique can be used to elicit behaviour in zebrafish larvae.

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