Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis

Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis

Anna Coluccia,1 Fabio Ferretti,1 Andrea Fagiolini,2,3 Andrea Pozza1 1Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital, 2Department of Molecular Medicine, School of Medicine, University of Siena, 3Department of Mental Health, University of Siena...

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Autores principales: Coluccia A, Ferretti F, Fagiolini A, Pozza A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Obsessive-Compulsive Disorder
Youth
Functioning
Social quality of life
Severity
Case-control study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/8fa9ce42ffdc4185b9f4c3820ebeb2b7
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spelling oai:doaj.org-article:8fa9ce42ffdc4185b9f4c3820ebeb2b72021-12-02T00:25:38ZQuality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis1178-2021https://doaj.org/article/8fa9ce42ffdc4185b9f4c3820ebeb2b72017-02-01T00:00:00Zhttps://www.dovepress.com/quality-of-life-in-children-and-adolescents-with-obsessivendashcompuls-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Anna Coluccia,1 Fabio Ferretti,1 Andrea Fagiolini,2,3 Andrea Pozza1 1Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital, 2Department of Molecular Medicine, School of Medicine, University of Siena, 3Department of Mental Health, University of Siena Medical Center (AOUS), Siena, Italy Abstract: Obsessive–compulsive disorder (OCD) is a seriously impairing psychiatric condition that affects 1%–3% of youth. Investigating the quality of life (QOL) is an important issue for treatment planning of this disorder, as targeting symptoms without taking it into account may bias assessment and prognosis when the patient presents with reduced symptoms that do not correspond to improved QOL. However, QOL in young individuals with OCD has been under-studied. This meta-analysis summarized current evidence that assessed differences in global, social and school QOL dimensions, between children/adolescents with OCD and screened controls. Age, sex and OCD severity were examined as moderators. Case–control studies were included if children/adolescents with primary OCD were compared with screened controls on validated self-reported QOL outcomes. Online databases (January 1966–January 2016) were searched. Five case–control studies were included (n=543, 17 effect sizes overall). On global QOL, a large effect size emerged (d=-1.16, P<0.001), suggesting that individuals with OCD had lower global QOL than controls. Moderate effect sizes emerged for school (d=-0.61, P<0.01) and social QOL (d=-0.54, P<0.01), respectively, indicating worse QOL on these domains for individuals with OCD. For samples with higher OCD severity, global QOL of individuals with OCD was lower than that for controls (β=-0.02, P<0.05). For samples with lower percentages of females, global QOL of individuals with OCD was more impaired (β=0.02, P<0.001). Age was not correlated with effect sizes. Assessment and treatment should target QOL for young males suffering from more severe OCD. The small number of included studies highlighted that QOL is under-recognized. Future research should focus on additional QOL domains and compare which ones are impaired among individuals with OCD compared with other psychiatric conditions. Overall, the results pointed out the importance of addressing QOL in both practice and research on assessment and treatment of children/adolescents with this condition. Keywords: obsessive–compulsive disorder, youth, functioning, social quality of life, severity, case–control studyColuccia AFerretti FFagiolini APozza ADove Medical PressarticleObsessive-Compulsive DisorderYouthFunctioningSocial quality of lifeSeverityCase-control study.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 597-608 (2017)
institution DOAJ
collection DOAJ
language EN
topic Obsessive-Compulsive Disorder
Youth
Functioning
Social quality of life
Severity
Case-control study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Obsessive-Compulsive Disorder
Youth
Functioning
Social quality of life
Severity
Case-control study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Coluccia A
Ferretti F
Fagiolini A
Pozza A
Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
description Anna Coluccia,1 Fabio Ferretti,1 Andrea Fagiolini,2,3 Andrea Pozza1 1Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital, 2Department of Molecular Medicine, School of Medicine, University of Siena, 3Department of Mental Health, University of Siena Medical Center (AOUS), Siena, Italy Abstract: Obsessive–compulsive disorder (OCD) is a seriously impairing psychiatric condition that affects 1%–3% of youth. Investigating the quality of life (QOL) is an important issue for treatment planning of this disorder, as targeting symptoms without taking it into account may bias assessment and prognosis when the patient presents with reduced symptoms that do not correspond to improved QOL. However, QOL in young individuals with OCD has been under-studied. This meta-analysis summarized current evidence that assessed differences in global, social and school QOL dimensions, between children/adolescents with OCD and screened controls. Age, sex and OCD severity were examined as moderators. Case–control studies were included if children/adolescents with primary OCD were compared with screened controls on validated self-reported QOL outcomes. Online databases (January 1966–January 2016) were searched. Five case–control studies were included (n=543, 17 effect sizes overall). On global QOL, a large effect size emerged (d=-1.16, P<0.001), suggesting that individuals with OCD had lower global QOL than controls. Moderate effect sizes emerged for school (d=-0.61, P<0.01) and social QOL (d=-0.54, P<0.01), respectively, indicating worse QOL on these domains for individuals with OCD. For samples with higher OCD severity, global QOL of individuals with OCD was lower than that for controls (β=-0.02, P<0.05). For samples with lower percentages of females, global QOL of individuals with OCD was more impaired (β=0.02, P<0.001). Age was not correlated with effect sizes. Assessment and treatment should target QOL for young males suffering from more severe OCD. The small number of included studies highlighted that QOL is under-recognized. Future research should focus on additional QOL domains and compare which ones are impaired among individuals with OCD compared with other psychiatric conditions. Overall, the results pointed out the importance of addressing QOL in both practice and research on assessment and treatment of children/adolescents with this condition. Keywords: obsessive–compulsive disorder, youth, functioning, social quality of life, severity, case–control study
format article
author Coluccia A
Ferretti F
Fagiolini A
Pozza A
author_facet Coluccia A
Ferretti F
Fagiolini A
Pozza A
author_sort Coluccia A
title Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
title_short Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
title_full Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
title_fullStr Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
title_full_unstemmed Quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
title_sort quality of life in children and adolescents with obsessive–compulsive disorder: a systematic review and meta-analysis
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/8fa9ce42ffdc4185b9f4c3820ebeb2b7
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AT pozzaa qualityoflifeinchildrenandadolescentswithobsessivendashcompulsivedisorderasystematicreviewandmetaanalysis
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