EBV based cancer prevention and therapy in nasopharyngeal carcinoma

Abstract Epstein–Barr virus is an important cancer causing virus. Nasopharyngeal carcinoma is an infection-related cancer strongly driven by Epstein–Barr virus. In this cancer model, we identified the major host targets of latent membrane protein 1 which is a driving oncogene encoded by Epstein–Barr...

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Autor principal:	Ya Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8fadfabaee38471eb4d3e1eb3e25a95b
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spelling	oai:doaj.org-article:8fadfabaee38471eb4d3e1eb3e25a95b2021-12-02T13:41:45ZEBV based cancer prevention and therapy in nasopharyngeal carcinoma10.1038/s41698-017-0018-x2397-768Xhttps://doaj.org/article/8fadfabaee38471eb4d3e1eb3e25a95b2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0018-xhttps://doaj.org/toc/2397-768XAbstract Epstein–Barr virus is an important cancer causing virus. Nasopharyngeal carcinoma is an infection-related cancer strongly driven by Epstein–Barr virus. In this cancer model, we identified the major host targets of latent membrane protein 1 which is a driving oncogene encoded by Epstein–Barr virus in latency infection. latent membrane protein 1 activates several oncogenic signaling axes causing multiple malignant phenotypes and therapeutic resistance. Also, Epstein–Barr virus up-regulates DNA methyltransferase 1 and mediates onco-epigenetic effects in the carcinogenesis. The collaborating pathways activated by latent membrane protein 1 constructs an oncogenic signaling network, which makes latent membrane protein 1 an important potential target for effective treatment or preventive intervention. In Epstein–Barr virus lytic phase, the plasma level of Epstein–Barr virus DNA is considered as a distinguishing marker for nasopharyngeal carcinoma in subjects from healthy high-risk populations and is also a novel prognostic marker in Epstein–Barr virus-positive nasopharyngeal carcinoma. Now the early detection and screening of the lytic proteins and Epstein–Barr virus DNA have been applied to clinical and high-risk population. The knowledge generated regarding Epstein–Barr virus can be used in Epstein–Barr virus based precision cancer prevention and therapy in the near future.Ya CaoNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ya Cao EBV based cancer prevention and therapy in nasopharyngeal carcinoma
description	Abstract Epstein–Barr virus is an important cancer causing virus. Nasopharyngeal carcinoma is an infection-related cancer strongly driven by Epstein–Barr virus. In this cancer model, we identified the major host targets of latent membrane protein 1 which is a driving oncogene encoded by Epstein–Barr virus in latency infection. latent membrane protein 1 activates several oncogenic signaling axes causing multiple malignant phenotypes and therapeutic resistance. Also, Epstein–Barr virus up-regulates DNA methyltransferase 1 and mediates onco-epigenetic effects in the carcinogenesis. The collaborating pathways activated by latent membrane protein 1 constructs an oncogenic signaling network, which makes latent membrane protein 1 an important potential target for effective treatment or preventive intervention. In Epstein–Barr virus lytic phase, the plasma level of Epstein–Barr virus DNA is considered as a distinguishing marker for nasopharyngeal carcinoma in subjects from healthy high-risk populations and is also a novel prognostic marker in Epstein–Barr virus-positive nasopharyngeal carcinoma. Now the early detection and screening of the lytic proteins and Epstein–Barr virus DNA have been applied to clinical and high-risk population. The knowledge generated regarding Epstein–Barr virus can be used in Epstein–Barr virus based precision cancer prevention and therapy in the near future.
format	article
author	Ya Cao
author_facet	Ya Cao
author_sort	Ya Cao
title	EBV based cancer prevention and therapy in nasopharyngeal carcinoma
title_short	EBV based cancer prevention and therapy in nasopharyngeal carcinoma
title_full	EBV based cancer prevention and therapy in nasopharyngeal carcinoma
title_fullStr	EBV based cancer prevention and therapy in nasopharyngeal carcinoma
title_full_unstemmed	EBV based cancer prevention and therapy in nasopharyngeal carcinoma
title_sort	ebv based cancer prevention and therapy in nasopharyngeal carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8fadfabaee38471eb4d3e1eb3e25a95b
work_keys_str_mv	AT yacao ebvbasedcancerpreventionandtherapyinnasopharyngealcarcinoma
_version_	1718392568072372224

EBV based cancer prevention and therapy in nasopharyngeal carcinoma

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