The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.

Histone acetylation/deacetylation is an important chromatin modification for epigenetic regulation of gene expression. Silent information regulation2 (Sir2)-related sirtuins are nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylases (HDAC). The mammalian sirtuin family comprises 7...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaochao Zhong, Hua Zhang, Yu Zhao, Qianwen Sun, Yongfeng Hu, Hai Peng, Dao-Xiu Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8fb19763dfd142a9931fdd678c9cb84c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8fb19763dfd142a9931fdd678c9cb84c
record_format	dspace
spelling	oai:doaj.org-article:8fb19763dfd142a9931fdd678c9cb84c2021-11-18T07:40:10ZThe rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.1932-620310.1371/journal.pone.0066807https://doaj.org/article/8fb19763dfd142a9931fdd678c9cb84c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23825566/?tool=EBIhttps://doaj.org/toc/1932-6203Histone acetylation/deacetylation is an important chromatin modification for epigenetic regulation of gene expression. Silent information regulation2 (Sir2)-related sirtuins are nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylases (HDAC). The mammalian sirtuin family comprises 7 members (SIRT1-7) that act in different cellular compartments to regulate metabolism and aging. The rice genome contains only two Sir2-related genes: OsSRT1 (or SRT701) and OsSRT2 (orSRT702). OsSRT1 is closely related to the mammalian SIRT6, while OsSRT2 is homologous to SIRT4. Previous work has shown that OsSRT1 is required for the safeguard against genome instability and cell damage in rice plant. In this work we investigated the role of OsSRT1 on genome-wide acetylation of histone H3 lysine 9 (H3K9ac) and studied the genome-wide binding targets of OsSRT1. The study reveals that OsSRT1 binds to loci with relatively low levels of H3K9ac and directly regulates H3K9ac and expression of many genes that are related to stress and metabolism, indicating that OsSRT1 is an important site-specific histone deacetylase for gene regulation in rice. In addition, OsSRT1 is found to also target to several families of transposable elements, suggesting that OsSRT1 is directly involved in transposable element repression.Xiaochao ZhongHua ZhangYu ZhaoQianwen SunYongfeng HuHai PengDao-Xiu ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66807 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaochao Zhong Hua Zhang Yu Zhao Qianwen Sun Yongfeng Hu Hai Peng Dao-Xiu Zhou The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
description	Histone acetylation/deacetylation is an important chromatin modification for epigenetic regulation of gene expression. Silent information regulation2 (Sir2)-related sirtuins are nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylases (HDAC). The mammalian sirtuin family comprises 7 members (SIRT1-7) that act in different cellular compartments to regulate metabolism and aging. The rice genome contains only two Sir2-related genes: OsSRT1 (or SRT701) and OsSRT2 (orSRT702). OsSRT1 is closely related to the mammalian SIRT6, while OsSRT2 is homologous to SIRT4. Previous work has shown that OsSRT1 is required for the safeguard against genome instability and cell damage in rice plant. In this work we investigated the role of OsSRT1 on genome-wide acetylation of histone H3 lysine 9 (H3K9ac) and studied the genome-wide binding targets of OsSRT1. The study reveals that OsSRT1 binds to loci with relatively low levels of H3K9ac and directly regulates H3K9ac and expression of many genes that are related to stress and metabolism, indicating that OsSRT1 is an important site-specific histone deacetylase for gene regulation in rice. In addition, OsSRT1 is found to also target to several families of transposable elements, suggesting that OsSRT1 is directly involved in transposable element repression.
format	article
author	Xiaochao Zhong Hua Zhang Yu Zhao Qianwen Sun Yongfeng Hu Hai Peng Dao-Xiu Zhou
author_facet	Xiaochao Zhong Hua Zhang Yu Zhao Qianwen Sun Yongfeng Hu Hai Peng Dao-Xiu Zhou
author_sort	Xiaochao Zhong
title	The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
title_short	The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
title_full	The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
title_fullStr	The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
title_full_unstemmed	The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.
title_sort	rice nad(+)-dependent histone deacetylase ossrt1 targets preferentially to stress- and metabolism-related genes and transposable elements.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8fb19763dfd142a9931fdd678c9cb84c
work_keys_str_mv	AT xiaochaozhong thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT huazhang thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT yuzhao thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT qianwensun thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT yongfenghu thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT haipeng thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT daoxiuzhou thericenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT xiaochaozhong ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT huazhang ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT yuzhao ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT qianwensun ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT yongfenghu ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT haipeng ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements AT daoxiuzhou ricenaddependenthistonedeacetylaseossrt1targetspreferentiallytostressandmetabolismrelatedgenesandtransposableelements
_version_	1718423111297138688

The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements.

Ejemplares similares