Inflammation-related plasma protein levels and association with adiposity measurements in young adults

Abstract Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Subjects from a populat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susanna Klevebro, Sophia Björkander, Sandra Ekström, Simon K. Merid, Olena Gruzieva, Anders Mälarstig, Åsa Johansson, Inger Kull, Anna Bergström, Erik Melén
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8fb376d9bf5c4a968c68c93556896ba9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8fb376d9bf5c4a968c68c93556896ba9
record_format	dspace
spelling	oai:doaj.org-article:8fb376d9bf5c4a968c68c93556896ba92021-12-02T15:56:42ZInflammation-related plasma protein levels and association with adiposity measurements in young adults10.1038/s41598-021-90843-x2045-2322https://doaj.org/article/8fb376d9bf5c4a968c68c93556896ba92021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90843-xhttps://doaj.org/toc/2045-2322Abstract Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Subjects from a population-based birth cohort with a mean age of 22.5 years were included in the study population (n = 2074). Protein levels were analyzed using the Olink Proseek Multiplex Inflammation panel. Percentage body fat (%BF) and visceral fat rating (VFR) measurements were collected using Tanita MC 780 body composition monitor. Linear regression of standardized values was used to investigate associations. Potential effect modifications by sex and BMI category were assessed. Of 71 investigated proteins, 54 were significantly associated with all adiposity measurements [%BF, body mass index (BMI), VFR and waist circumference]. Among proteins associated with %BF, seven showed a larger or unique association in overweight/obese subjects and three showed a significant effect modification by sex. Fourteen proteins more strongly associated with VFR in females compared to males. Adipose-associated systemic inflammation was observed in this young adult population. Sex and adiposity localization influenced some of the associations. Our results highlight specific proteins as suitable biomarkers related to adiposity.Susanna KlevebroSophia BjörkanderSandra EkströmSimon K. MeridOlena GruzievaAnders MälarstigÅsa JohanssonInger KullAnna BergströmErik MelénNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanna Klevebro Sophia Björkander Sandra Ekström Simon K. Merid Olena Gruzieva Anders Mälarstig Åsa Johansson Inger Kull Anna Bergström Erik Melén Inflammation-related plasma protein levels and association with adiposity measurements in young adults
description	Abstract Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Subjects from a population-based birth cohort with a mean age of 22.5 years were included in the study population (n = 2074). Protein levels were analyzed using the Olink Proseek Multiplex Inflammation panel. Percentage body fat (%BF) and visceral fat rating (VFR) measurements were collected using Tanita MC 780 body composition monitor. Linear regression of standardized values was used to investigate associations. Potential effect modifications by sex and BMI category were assessed. Of 71 investigated proteins, 54 were significantly associated with all adiposity measurements [%BF, body mass index (BMI), VFR and waist circumference]. Among proteins associated with %BF, seven showed a larger or unique association in overweight/obese subjects and three showed a significant effect modification by sex. Fourteen proteins more strongly associated with VFR in females compared to males. Adipose-associated systemic inflammation was observed in this young adult population. Sex and adiposity localization influenced some of the associations. Our results highlight specific proteins as suitable biomarkers related to adiposity.
format	article
author	Susanna Klevebro Sophia Björkander Sandra Ekström Simon K. Merid Olena Gruzieva Anders Mälarstig Åsa Johansson Inger Kull Anna Bergström Erik Melén
author_facet	Susanna Klevebro Sophia Björkander Sandra Ekström Simon K. Merid Olena Gruzieva Anders Mälarstig Åsa Johansson Inger Kull Anna Bergström Erik Melén
author_sort	Susanna Klevebro
title	Inflammation-related plasma protein levels and association with adiposity measurements in young adults
title_short	Inflammation-related plasma protein levels and association with adiposity measurements in young adults
title_full	Inflammation-related plasma protein levels and association with adiposity measurements in young adults
title_fullStr	Inflammation-related plasma protein levels and association with adiposity measurements in young adults
title_full_unstemmed	Inflammation-related plasma protein levels and association with adiposity measurements in young adults
title_sort	inflammation-related plasma protein levels and association with adiposity measurements in young adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8fb376d9bf5c4a968c68c93556896ba9
work_keys_str_mv	AT susannaklevebro inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT sophiabjorkander inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT sandraekstrom inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT simonkmerid inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT olenagruzieva inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT andersmalarstig inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT asajohansson inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT ingerkull inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT annabergstrom inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults AT erikmelen inflammationrelatedplasmaproteinlevelsandassociationwithadipositymeasurementsinyoungadults
_version_	1718385404700262400

Inflammation-related plasma protein levels and association with adiposity measurements in young adults

Ejemplares similares