Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low in hyperdiploid cases and transcriptional dysregula...

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Autores principales:	Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H. Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T. Odom, Linda Olsson, Naveen Ravi, Eleanor L. Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
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spelling	oai:doaj.org-article:8fb5db51725140f997f862673ee0cf512021-12-02T17:02:02ZProteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia10.1038/s41467-019-09469-32041-1723https://doaj.org/article/8fb5db51725140f997f862673ee0cf512019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09469-3https://doaj.org/toc/2041-1723High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low in hyperdiploid cases and transcriptional dysregulation in relation to topologically associating domain borders in some of these cases.Minjun YangMattias VesterlundIoannis SiavelisLarissa H. Moura-CastroAnders CastorThoas FioretosRozbeh JafariHenrik LilljebjörnDuncan T. OdomLinda OlssonNaveen RaviEleanor L. WoodwardLouise HarewoodJanne LehtiöKajsa PaulssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minjun Yang Mattias Vesterlund Ioannis Siavelis Larissa H. Moura-Castro Anders Castor Thoas Fioretos Rozbeh Jafari Henrik Lilljebjörn Duncan T. Odom Linda Olsson Naveen Ravi Eleanor L. Woodward Louise Harewood Janne Lehtiö Kajsa Paulsson Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
description	High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low in hyperdiploid cases and transcriptional dysregulation in relation to topologically associating domain borders in some of these cases.
format	article
author	Minjun Yang Mattias Vesterlund Ioannis Siavelis Larissa H. Moura-Castro Anders Castor Thoas Fioretos Rozbeh Jafari Henrik Lilljebjörn Duncan T. Odom Linda Olsson Naveen Ravi Eleanor L. Woodward Louise Harewood Janne Lehtiö Kajsa Paulsson
author_facet	Minjun Yang Mattias Vesterlund Ioannis Siavelis Larissa H. Moura-Castro Anders Castor Thoas Fioretos Rozbeh Jafari Henrik Lilljebjörn Duncan T. Odom Linda Olsson Naveen Ravi Eleanor L. Woodward Louise Harewood Janne Lehtiö Kajsa Paulsson
author_sort	Minjun Yang
title	Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
title_short	Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
title_full	Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
title_fullStr	Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
title_full_unstemmed	Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
title_sort	proteogenomics and hi-c reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
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_version_	1718381982027612160

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

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