Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process

Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin is an important protein found in the red cells of many animals. In humans, the hemoglobin is mainly distributed in the red blood cell. Single amino acid substitutio...

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Autor principal:	Viroj Wiwanitkit
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8fb70e377ec8409ca9ad5704612dd555
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spelling	oai:doaj.org-article:8fb70e377ec8409ca9ad5704612dd5552021-12-02T02:49:07ZSingle amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process1176-91141178-2013https://doaj.org/article/8fb70e377ec8409ca9ad5704612dd5552008-06-01T00:00:00Zhttp://www.dovepress.com/single-amino-acid-substitution-in-important-hemoglobinopathies-does-no-a1841https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin is an important protein found in the red cells of many animals. In humans, the hemoglobin is mainly distributed in the red blood cell. Single amino acid substitution is the main pathogenesis of most hemoglobin disorders. Here, the author used a new gene ontology technology to predict the molecular function and biological process of four important hemoglobin disorders with single substitution. The four studied important abnormal hemoglobins (Hb) with single substitution included Hb S, Hb E, Hb C, and Hb J-Baltimore. Using the GoFigure server, the molecular function and biological process in normal and abnormal hemoglobins was predicted. Compared with normal hemoglobin, all studied abnormal hemoglobins had the same function and biological process. This indicated that the overall function of oxygen transportation is not disturbed in the studied hemoglobin disorders. Clinical findings of oxygen depletion in abnormal hemoglobin should therefore be due to the other processes rather than genomics, proteomics, and expression levels.Keywords: hemoglobin, amino acid, substitution, function Viroj WiwanitkitDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 2, Pp 225-227 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Viroj Wiwanitkit Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
description	Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin is an important protein found in the red cells of many animals. In humans, the hemoglobin is mainly distributed in the red blood cell. Single amino acid substitution is the main pathogenesis of most hemoglobin disorders. Here, the author used a new gene ontology technology to predict the molecular function and biological process of four important hemoglobin disorders with single substitution. The four studied important abnormal hemoglobins (Hb) with single substitution included Hb S, Hb E, Hb C, and Hb J-Baltimore. Using the GoFigure server, the molecular function and biological process in normal and abnormal hemoglobins was predicted. Compared with normal hemoglobin, all studied abnormal hemoglobins had the same function and biological process. This indicated that the overall function of oxygen transportation is not disturbed in the studied hemoglobin disorders. Clinical findings of oxygen depletion in abnormal hemoglobin should therefore be due to the other processes rather than genomics, proteomics, and expression levels.Keywords: hemoglobin, amino acid, substitution, function
format	article
author	Viroj Wiwanitkit
author_facet	Viroj Wiwanitkit
author_sort	Viroj Wiwanitkit
title	Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
title_short	Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
title_full	Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
title_fullStr	Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
title_full_unstemmed	Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
title_sort	single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/8fb70e377ec8409ca9ad5704612dd555
work_keys_str_mv	AT virojwiwanitkit singleaminoacidsubstitutioninimportanthemoglobinopathiesdoesnotdisturbmolecularfunctionandbiologicalprocess
_version_	1718402112776306688

Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process

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