Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy

Abstract A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic...

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Autores principales:	Kota Utsumi, Kouji Takano, Yoji Okahara, Tetsuo Komori, Osamu Onodera, Kenji Kansaku
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8fbee4ec378949398d59d918a441a055
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spelling	oai:doaj.org-article:8fbee4ec378949398d59d918a441a0552021-12-02T15:07:57ZOperation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy10.1038/s41598-018-20125-62045-2322https://doaj.org/article/8fbee4ec378949398d59d918a441a0552018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20125-6https://doaj.org/toc/2045-2322Abstract A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it has not been tested systematically in Duchenne muscular dystrophy (DMD), which is a severe type of muscular dystrophy due to the loss of dystrophin and is often accompanied by progressive muscle weakness and wasting. Here, we investigated the efficacy of a P300-based BCI for patients with DMD. Eight bedridden patients with DMD and eight age- and gender-matched able-bodied controls were instructed to input hiragana characters. We used a region-based, two-step P300-based BCI with green/blue flicker stimuli. EEG data were recorded, and a linear discriminant analysis distinguished the target from other non-targets. The mean online accuracy of inputted characters (accuracy for the two-step procedure) was 71.6% for patients with DMD and 80.6% for controls, with no significant difference between the patients and controls. The P300-based BCI was operated successfully by individuals with DMD in an advanced stage and these findings suggest that this technology may be beneficial for patients with this disease.Kota UtsumiKouji TakanoYoji OkaharaTetsuo KomoriOsamu OnoderaKenji KansakuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kota Utsumi Kouji Takano Yoji Okahara Tetsuo Komori Osamu Onodera Kenji Kansaku Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
description	Abstract A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it has not been tested systematically in Duchenne muscular dystrophy (DMD), which is a severe type of muscular dystrophy due to the loss of dystrophin and is often accompanied by progressive muscle weakness and wasting. Here, we investigated the efficacy of a P300-based BCI for patients with DMD. Eight bedridden patients with DMD and eight age- and gender-matched able-bodied controls were instructed to input hiragana characters. We used a region-based, two-step P300-based BCI with green/blue flicker stimuli. EEG data were recorded, and a linear discriminant analysis distinguished the target from other non-targets. The mean online accuracy of inputted characters (accuracy for the two-step procedure) was 71.6% for patients with DMD and 80.6% for controls, with no significant difference between the patients and controls. The P300-based BCI was operated successfully by individuals with DMD in an advanced stage and these findings suggest that this technology may be beneficial for patients with this disease.
format	article
author	Kota Utsumi Kouji Takano Yoji Okahara Tetsuo Komori Osamu Onodera Kenji Kansaku
author_facet	Kota Utsumi Kouji Takano Yoji Okahara Tetsuo Komori Osamu Onodera Kenji Kansaku
author_sort	Kota Utsumi
title	Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
title_short	Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
title_full	Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
title_fullStr	Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
title_full_unstemmed	Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy
title_sort	operation of a p300-based brain-computer interface in patients with duchenne muscular dystrophy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8fbee4ec378949398d59d918a441a055
work_keys_str_mv	AT kotautsumi operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy AT koujitakano operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy AT yojiokahara operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy AT tetsuokomori operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy AT osamuonodera operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy AT kenjikansaku operationofap300basedbraincomputerinterfaceinpatientswithduchennemusculardystrophy
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Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy

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