Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis

Objective Associations between serum lipids and their individual components with premenopausal breast cancer risk are unclear. This meta-analysis summarized the literature on serum lipids and premenopausal breast cancer risk to elucidate their relationship. Methods Eligible studies were identified b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Wu, Xun Lei, Xianjun Pan, Xiaohua Zeng, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8fbf1b2e5d80402f9381779d616a7336
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8fbf1b2e5d80402f9381779d616a7336
record_format	dspace
spelling	oai:doaj.org-article:8fbf1b2e5d80402f9381779d616a73362021-12-02T08:05:10ZAssociation between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis1473-230010.1177/03000605211061033https://doaj.org/article/8fbf1b2e5d80402f9381779d616a73362021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211061033https://doaj.org/toc/1473-2300Objective Associations between serum lipids and their individual components with premenopausal breast cancer risk are unclear. This meta-analysis summarized the literature on serum lipids and premenopausal breast cancer risk to elucidate their relationship. Methods Eligible studies were identified by searching the PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases until 31 December 2020. Standardized mean difference (SMD) scores with 95% confidence intervals (95%CIs) were used to assess the impact of serum lipids on premenopausal breast cancer risk. The I 2 statistic was calculated to measure the percentage of heterogeneity, and Egger’s test was performed to measure publication bias. Results Thirteen studies were included. The SMD scores of triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were 12.90 (95%CI: 7.19–18.61) and 31.43 (95%CI: 8.72–54.15), respectively. The SMD scores of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were not significantly different between the groups. The included studies were highly heterogeneous. There were no publication biases found in TC, LDL-C, or HDL-C analyses, whereas publication bias was present in the TG analysis. Conclusions TG and LDL-C were higher in premenopausal breast cancer patients than in women without breast cancer. However, no significant differences were found in TC or HDL-C levels.Jing WuXun LeiXianjun PanXiaohua ZengWei LiSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jing Wu Xun Lei Xianjun Pan Xiaohua Zeng Wei Li Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
description	Objective Associations between serum lipids and their individual components with premenopausal breast cancer risk are unclear. This meta-analysis summarized the literature on serum lipids and premenopausal breast cancer risk to elucidate their relationship. Methods Eligible studies were identified by searching the PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases until 31 December 2020. Standardized mean difference (SMD) scores with 95% confidence intervals (95%CIs) were used to assess the impact of serum lipids on premenopausal breast cancer risk. The I 2 statistic was calculated to measure the percentage of heterogeneity, and Egger’s test was performed to measure publication bias. Results Thirteen studies were included. The SMD scores of triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were 12.90 (95%CI: 7.19–18.61) and 31.43 (95%CI: 8.72–54.15), respectively. The SMD scores of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were not significantly different between the groups. The included studies were highly heterogeneous. There were no publication biases found in TC, LDL-C, or HDL-C analyses, whereas publication bias was present in the TG analysis. Conclusions TG and LDL-C were higher in premenopausal breast cancer patients than in women without breast cancer. However, no significant differences were found in TC or HDL-C levels.
format	article
author	Jing Wu Xun Lei Xianjun Pan Xiaohua Zeng Wei Li
author_facet	Jing Wu Xun Lei Xianjun Pan Xiaohua Zeng Wei Li
author_sort	Jing Wu
title	Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
title_short	Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
title_full	Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
title_fullStr	Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
title_full_unstemmed	Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
title_sort	association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/8fbf1b2e5d80402f9381779d616a7336
work_keys_str_mv	AT jingwu associationbetweenserumlipidsandbreastcancerriskinpremenopausalwomensystematicreviewandmetaanalysis AT xunlei associationbetweenserumlipidsandbreastcancerriskinpremenopausalwomensystematicreviewandmetaanalysis AT xianjunpan associationbetweenserumlipidsandbreastcancerriskinpremenopausalwomensystematicreviewandmetaanalysis AT xiaohuazeng associationbetweenserumlipidsandbreastcancerriskinpremenopausalwomensystematicreviewandmetaanalysis AT weili associationbetweenserumlipidsandbreastcancerriskinpremenopausalwomensystematicreviewandmetaanalysis
_version_	1718398672619700224

Association between serum lipids and breast cancer risk in premenopausal women: systematic review and meta-analysis

Ejemplares similares