International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Abstract We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries ( www.covidclinical...

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Autores principales:	Gabriel A. Brat, Griffin M. Weber, Nils Gehlenborg, Paul Avillach, Nathan P. Palmer, Luca Chiovato, James Cimino, Lemuel R. Waitman, Gilbert S. Omenn, Alberto Malovini, Jason H. Moore, Brett K. Beaulieu-Jones, Valentina Tibollo, Shawn N. Murphy, Sehi L’ Yi, Mark S. Keller, Riccardo Bellazzi, David A. Hanauer, Arnaud Serret-Larmande, Alba Gutierrez-Sacristan, John J. Holmes, Douglas S. Bell, Kenneth D. Mandl, Robert W. Follett, Jeffrey G. Klann, Douglas A. Murad, Luigia Scudeller, Mauro Bucalo, Katie Kirchoff, Jean Craig, Jihad Obeid, Vianney Jouhet, Romain Griffier, Sebastien Cossin, Bertrand Moal, Lav P. Patel, Antonio Bellasi, Hans U. Prokosch, Detlef Kraska, Piotr Sliz, Amelia L. M. Tan, Kee Yuan Ngiam, Alberto Zambelli, Danielle L. Mowery, Emily Schiver, Batsal Devkota, Robert L. Bradford, Mohamad Daniar, Christel Daniel, Vincent Benoit, Romain Bey, Nicolas Paris, Patricia Serre, Nina Orlova, Julien Dubiel, Martin Hilka, Anne Sophie Jannot, Stephane Breant, Judith Leblanc, Nicolas Griffon, Anita Burgun, Melodie Bernaux, Arnaud Sandrin, Elisa Salamanca, Sylvie Cormont, Thomas Ganslandt, Tobias Gradinger, Julien Champ, Martin Boeker, Patricia Martel, Loic Esteve, Alexandre Gramfort, Olivier Grisel, Damien Leprovost, Thomas Moreau, Gael Varoquaux, Jill-Jênn Vie, Demian Wassermann, Arthur Mensch, Charlotte Caucheteux, Christian Haverkamp, Guillaume Lemaitre, Silvano Bosari, Ian D. Krantz, Andrew South, Tianxi Cai, Isaac S. Kohane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/8fc2d00530b14deda00eb854c574f234
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spelling	oai:doaj.org-article:8fc2d00530b14deda00eb854c574f2342021-12-02T17:08:21ZInternational electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium10.1038/s41746-020-00308-02398-6352https://doaj.org/article/8fc2d00530b14deda00eb854c574f2342020-08-01T00:00:00Zhttps://doi.org/10.1038/s41746-020-00308-0https://doaj.org/toc/2398-6352Abstract We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries ( www.covidclinical.net ). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.Gabriel A. BratGriffin M. WeberNils GehlenborgPaul AvillachNathan P. PalmerLuca ChiovatoJames CiminoLemuel R. WaitmanGilbert S. OmennAlberto MaloviniJason H. MooreBrett K. Beaulieu-JonesValentina TibolloShawn N. MurphySehi L’ YiMark S. KellerRiccardo BellazziDavid A. HanauerArnaud Serret-LarmandeAlba Gutierrez-SacristanJohn J. HolmesDouglas S. BellKenneth D. MandlRobert W. FollettJeffrey G. KlannDouglas A. MuradLuigia ScudellerMauro BucaloKatie KirchoffJean CraigJihad ObeidVianney JouhetRomain GriffierSebastien CossinBertrand MoalLav P. PatelAntonio BellasiHans U. ProkoschDetlef KraskaPiotr SlizAmelia L. M. TanKee Yuan NgiamAlberto ZambelliDanielle L. MoweryEmily SchiverBatsal DevkotaRobert L. BradfordMohamad DaniarChristel DanielVincent BenoitRomain BeyNicolas ParisPatricia SerreNina OrlovaJulien DubielMartin HilkaAnne Sophie JannotStephane BreantJudith LeblancNicolas GriffonAnita BurgunMelodie BernauxArnaud SandrinElisa SalamancaSylvie CormontThomas GanslandtTobias GradingerJulien ChampMartin BoekerPatricia MartelLoic EsteveAlexandre GramfortOlivier GriselDamien LeprovostThomas MoreauGael VaroquauxJill-Jênn VieDemian WassermannArthur MenschCharlotte CaucheteuxChristian HaverkampGuillaume LemaitreSilvano BosariIan D. KrantzAndrew SouthTianxi CaiIsaac S. KohaneNature PortfolioarticleComputer applications to medicine. Medical informaticsR858-859.7ENnpj Digital Medicine, Vol 3, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Gabriel A. Brat Griffin M. Weber Nils Gehlenborg Paul Avillach Nathan P. Palmer Luca Chiovato James Cimino Lemuel R. Waitman Gilbert S. Omenn Alberto Malovini Jason H. Moore Brett K. Beaulieu-Jones Valentina Tibollo Shawn N. Murphy Sehi L’ Yi Mark S. Keller Riccardo Bellazzi David A. Hanauer Arnaud Serret-Larmande Alba Gutierrez-Sacristan John J. Holmes Douglas S. Bell Kenneth D. Mandl Robert W. Follett Jeffrey G. Klann Douglas A. Murad Luigia Scudeller Mauro Bucalo Katie Kirchoff Jean Craig Jihad Obeid Vianney Jouhet Romain Griffier Sebastien Cossin Bertrand Moal Lav P. Patel Antonio Bellasi Hans U. Prokosch Detlef Kraska Piotr Sliz Amelia L. M. Tan Kee Yuan Ngiam Alberto Zambelli Danielle L. Mowery Emily Schiver Batsal Devkota Robert L. Bradford Mohamad Daniar Christel Daniel Vincent Benoit Romain Bey Nicolas Paris Patricia Serre Nina Orlova Julien Dubiel Martin Hilka Anne Sophie Jannot Stephane Breant Judith Leblanc Nicolas Griffon Anita Burgun Melodie Bernaux Arnaud Sandrin Elisa Salamanca Sylvie Cormont Thomas Ganslandt Tobias Gradinger Julien Champ Martin Boeker Patricia Martel Loic Esteve Alexandre Gramfort Olivier Grisel Damien Leprovost Thomas Moreau Gael Varoquaux Jill-Jênn Vie Demian Wassermann Arthur Mensch Charlotte Caucheteux Christian Haverkamp Guillaume Lemaitre Silvano Bosari Ian D. Krantz Andrew South Tianxi Cai Isaac S. Kohane International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
description	Abstract We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries ( www.covidclinical.net ). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.
format	article
author	Gabriel A. Brat Griffin M. Weber Nils Gehlenborg Paul Avillach Nathan P. Palmer Luca Chiovato James Cimino Lemuel R. Waitman Gilbert S. Omenn Alberto Malovini Jason H. Moore Brett K. Beaulieu-Jones Valentina Tibollo Shawn N. Murphy Sehi L’ Yi Mark S. Keller Riccardo Bellazzi David A. Hanauer Arnaud Serret-Larmande Alba Gutierrez-Sacristan John J. Holmes Douglas S. Bell Kenneth D. Mandl Robert W. Follett Jeffrey G. Klann Douglas A. Murad Luigia Scudeller Mauro Bucalo Katie Kirchoff Jean Craig Jihad Obeid Vianney Jouhet Romain Griffier Sebastien Cossin Bertrand Moal Lav P. Patel Antonio Bellasi Hans U. Prokosch Detlef Kraska Piotr Sliz Amelia L. M. Tan Kee Yuan Ngiam Alberto Zambelli Danielle L. Mowery Emily Schiver Batsal Devkota Robert L. Bradford Mohamad Daniar Christel Daniel Vincent Benoit Romain Bey Nicolas Paris Patricia Serre Nina Orlova Julien Dubiel Martin Hilka Anne Sophie Jannot Stephane Breant Judith Leblanc Nicolas Griffon Anita Burgun Melodie Bernaux Arnaud Sandrin Elisa Salamanca Sylvie Cormont Thomas Ganslandt Tobias Gradinger Julien Champ Martin Boeker Patricia Martel Loic Esteve Alexandre Gramfort Olivier Grisel Damien Leprovost Thomas Moreau Gael Varoquaux Jill-Jênn Vie Demian Wassermann Arthur Mensch Charlotte Caucheteux Christian Haverkamp Guillaume Lemaitre Silvano Bosari Ian D. Krantz Andrew South Tianxi Cai Isaac S. Kohane
author_facet	Gabriel A. Brat Griffin M. Weber Nils Gehlenborg Paul Avillach Nathan P. Palmer Luca Chiovato James Cimino Lemuel R. Waitman Gilbert S. Omenn Alberto Malovini Jason H. Moore Brett K. Beaulieu-Jones Valentina Tibollo Shawn N. Murphy Sehi L’ Yi Mark S. Keller Riccardo Bellazzi David A. Hanauer Arnaud Serret-Larmande Alba Gutierrez-Sacristan John J. Holmes Douglas S. Bell Kenneth D. Mandl Robert W. Follett Jeffrey G. Klann Douglas A. Murad Luigia Scudeller Mauro Bucalo Katie Kirchoff Jean Craig Jihad Obeid Vianney Jouhet Romain Griffier Sebastien Cossin Bertrand Moal Lav P. Patel Antonio Bellasi Hans U. Prokosch Detlef Kraska Piotr Sliz Amelia L. M. Tan Kee Yuan Ngiam Alberto Zambelli Danielle L. Mowery Emily Schiver Batsal Devkota Robert L. Bradford Mohamad Daniar Christel Daniel Vincent Benoit Romain Bey Nicolas Paris Patricia Serre Nina Orlova Julien Dubiel Martin Hilka Anne Sophie Jannot Stephane Breant Judith Leblanc Nicolas Griffon Anita Burgun Melodie Bernaux Arnaud Sandrin Elisa Salamanca Sylvie Cormont Thomas Ganslandt Tobias Gradinger Julien Champ Martin Boeker Patricia Martel Loic Esteve Alexandre Gramfort Olivier Grisel Damien Leprovost Thomas Moreau Gael Varoquaux Jill-Jênn Vie Demian Wassermann Arthur Mensch Charlotte Caucheteux Christian Haverkamp Guillaume Lemaitre Silvano Bosari Ian D. Krantz Andrew South Tianxi Cai Isaac S. Kohane
author_sort	Gabriel A. Brat
title	International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
title_short	International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
title_full	International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
title_fullStr	International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
title_full_unstemmed	International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
title_sort	international electronic health record-derived covid-19 clinical course profiles: the 4ce consortium
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8fc2d00530b14deda00eb854c574f234
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International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

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