Quorum sensing modulates the formation of virulent Legionella persisters within infected cells

The pathogenic bacterium Legionella pneumophila infects lung macrophages and environmental amoebae. Here, Personnic et al. show that the pathogen reversibly forms virulent, antibiotic-tolerant subpopulations during infection of macrophages and amoebae, in a process regulated by the Lqs quorum-sensin...

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Autores principales:	Nicolas Personnic, Bianca Striednig, Emmanuelle Lezan, Christian Manske, Amanda Welin, Alexander Schmidt, Hubert Hilbi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8fc5c33498c943aab2c6d293ef4bafcd
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spelling	oai:doaj.org-article:8fc5c33498c943aab2c6d293ef4bafcd2021-12-02T16:57:22ZQuorum sensing modulates the formation of virulent Legionella persisters within infected cells10.1038/s41467-019-13021-82041-1723https://doaj.org/article/8fc5c33498c943aab2c6d293ef4bafcd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13021-8https://doaj.org/toc/2041-1723The pathogenic bacterium Legionella pneumophila infects lung macrophages and environmental amoebae. Here, Personnic et al. show that the pathogen reversibly forms virulent, antibiotic-tolerant subpopulations during infection of macrophages and amoebae, in a process regulated by the Lqs quorum-sensing system.Nicolas PersonnicBianca StriednigEmmanuelle LezanChristian ManskeAmanda WelinAlexander SchmidtHubert HilbiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Personnic Bianca Striednig Emmanuelle Lezan Christian Manske Amanda Welin Alexander Schmidt Hubert Hilbi Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
description	The pathogenic bacterium Legionella pneumophila infects lung macrophages and environmental amoebae. Here, Personnic et al. show that the pathogen reversibly forms virulent, antibiotic-tolerant subpopulations during infection of macrophages and amoebae, in a process regulated by the Lqs quorum-sensing system.
format	article
author	Nicolas Personnic Bianca Striednig Emmanuelle Lezan Christian Manske Amanda Welin Alexander Schmidt Hubert Hilbi
author_facet	Nicolas Personnic Bianca Striednig Emmanuelle Lezan Christian Manske Amanda Welin Alexander Schmidt Hubert Hilbi
author_sort	Nicolas Personnic
title	Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
title_short	Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
title_full	Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
title_fullStr	Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
title_full_unstemmed	Quorum sensing modulates the formation of virulent Legionella persisters within infected cells
title_sort	quorum sensing modulates the formation of virulent legionella persisters within infected cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8fc5c33498c943aab2c6d293ef4bafcd
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Quorum sensing modulates the formation of virulent Legionella persisters within infected cells

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