Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.

<h4>Rationale</h4>Both atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FE(NO)), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a physiological bronchodil...

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Autores principales: Andrei Malinovschi, Christer Janson, Marieann Högman, Giovanni Rolla, Kjell Torén, Dan Norbäck, Anna-Carin Olin
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Publicado: Public Library of Science (PLoS) 2012
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spelling oai:doaj.org-article:8fc72192b1f84289bef66bd7e917b2662021-11-18T07:20:48ZBronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.1932-620310.1371/journal.pone.0035725https://doaj.org/article/8fc72192b1f84289bef66bd7e917b2662012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22563393/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Both atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FE(NO)), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a physiological bronchodilating and bronchoprotective role.<h4>Objectives</h4>To investigate how the relation between FE(NO) and bronchial responsiveness is modulated by atopy and smoking habits.<h4>Methods</h4>Exhaled NO measurements and methacholine challenge were performed in 468 subjects from the random sample of three European Community Respiratory Health Survey II centers: Turin (Italy), Gothenburg and Uppsala (both Sweden). Atopy status was defined by using specific IgE measurements while smoking status was questionnaire-assessed.<h4>Main results</h4>Increased bronchial responsiveness was associated with increased FE(NO) levels in non-smokers (p = 0.02) and decreased FE(NO) levels in current smokers (p = 0.03). The negative association between bronchial responsiveness and FE(NO) was seen only in the group smoking less <10 cigarettes/day (p = 0.008). Increased bronchial responsiveness was associated with increased FE(NO) in atopic subjects (p = 0.04) while no significant association was found in non-atopic participants. The reported interaction between FE(NO) and smoking and atopy, respectively were maintained after adjusting for possible confounders (p-values<0.05).<h4>Conclusions</h4>The present study highlights the interactions of the relationship between FE(NO) and bronchial responsiveness with smoking and atopy, suggesting different mechanisms behind atopy- and smoking-related increases of bronchial responsiveness.Andrei MalinovschiChrister JansonMarieann HögmanGiovanni RollaKjell TorénDan NorbäckAnna-Carin OlinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35725 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Andrei Malinovschi
Christer Janson
Marieann Högman
Giovanni Rolla
Kjell Torén
Dan Norbäck
Anna-Carin Olin
Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
description <h4>Rationale</h4>Both atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FE(NO)), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a physiological bronchodilating and bronchoprotective role.<h4>Objectives</h4>To investigate how the relation between FE(NO) and bronchial responsiveness is modulated by atopy and smoking habits.<h4>Methods</h4>Exhaled NO measurements and methacholine challenge were performed in 468 subjects from the random sample of three European Community Respiratory Health Survey II centers: Turin (Italy), Gothenburg and Uppsala (both Sweden). Atopy status was defined by using specific IgE measurements while smoking status was questionnaire-assessed.<h4>Main results</h4>Increased bronchial responsiveness was associated with increased FE(NO) levels in non-smokers (p = 0.02) and decreased FE(NO) levels in current smokers (p = 0.03). The negative association between bronchial responsiveness and FE(NO) was seen only in the group smoking less <10 cigarettes/day (p = 0.008). Increased bronchial responsiveness was associated with increased FE(NO) in atopic subjects (p = 0.04) while no significant association was found in non-atopic participants. The reported interaction between FE(NO) and smoking and atopy, respectively were maintained after adjusting for possible confounders (p-values<0.05).<h4>Conclusions</h4>The present study highlights the interactions of the relationship between FE(NO) and bronchial responsiveness with smoking and atopy, suggesting different mechanisms behind atopy- and smoking-related increases of bronchial responsiveness.
format article
author Andrei Malinovschi
Christer Janson
Marieann Högman
Giovanni Rolla
Kjell Torén
Dan Norbäck
Anna-Carin Olin
author_facet Andrei Malinovschi
Christer Janson
Marieann Högman
Giovanni Rolla
Kjell Torén
Dan Norbäck
Anna-Carin Olin
author_sort Andrei Malinovschi
title Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
title_short Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
title_full Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
title_fullStr Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
title_full_unstemmed Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.
title_sort bronchial responsiveness is related to increased exhaled no (fe(no)) in non-smokers and decreased fe(no) in smokers.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/8fc72192b1f84289bef66bd7e917b266
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