Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia.

Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia.

Pulmonary surfactant protein D (SP-D) is a host defence lectin of the innate immune system that enhances clearance of pathogens and modulates inflammatory responses. Recently it has been found that systemic SP-D is associated with metabolic disturbances and that SP-D deficient mice are mildly obese....

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Main Authors: Jacob V Stidsen, Reza Khorooshi, Martin K U Rahbek, Katrine L Kirketerp-Møller, Pernille B L Hansen, Peter Bie, Karin Kejling, Susanne Mandrup, Samuel Hawgood, Ole Nielsen, Claus H Nielsen, Trevor Owens, Uffe Holmskov, Grith L Sørensen
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/8fc85292689b4985ab96e168c8f288eb
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https://doaj.org/article/8fc85292689b4985ab96e168c8f288eb

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