A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients’ prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic...

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Autores principales:	Adriana P. Mamede, Inês P. Santos, Ana L. M. Batista de Carvalho, Paulo Figueiredo, Maria C. Silva, Mariana V. Tavares, Maria P. M. Marques, Luís A. E. Batista de Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Raman spectroscopy FTIR spectroscopy breast cancer head and neck cancer alternative and complementary methodologies diagnosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8fcad4e656b8420685928bb5e9cbf07c
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spelling	oai:doaj.org-article:8fcad4e656b8420685928bb5e9cbf07c2021-11-11T15:28:39ZA New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance10.3390/cancers132153362072-6694https://doaj.org/article/8fcad4e656b8420685928bb5e9cbf07c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5336https://doaj.org/toc/2072-6694In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients’ prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be an ideal diagnostic method for early cancer diagnosis and surgical margins assessment, as a complement to histopathological analysis. Being highly sensitive, non-invasive and capable of real-time molecular imaging, Raman and Fourier transform infrared (FTIR) spectroscopies give information on the biochemical profile of the tissue under analysis, detecting the metabolic differences between healthy and cancerous portions of the same sample. This constitutes tremendous progress in the field, since the cancer-prompted morphological alterations often occur after the biochemical imbalances in the oncogenic process. Therefore, the early cancer-associated metabolic changes are unnoticed by the histopathologist. Additionally, Raman and FTIR spectroscopies significantly reduce the subjectivity linked to cancer diagnosis. This review focuses on breast and head and neck cancers, their clinical needs and the progress made to date using vibrational spectroscopy as a diagnostic technique prior to surgical intervention and intraoperative margin assessment.Adriana P. MamedeInês P. SantosAna L. M. Batista de CarvalhoPaulo FigueiredoMaria C. SilvaMariana V. TavaresMaria P. M. MarquesLuís A. E. Batista de CarvalhoMDPI AGarticleRaman spectroscopyFTIR spectroscopybreast cancerhead and neck canceralternative and complementary methodologiesdiagnosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5336, p 5336 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Raman spectroscopy FTIR spectroscopy breast cancer head and neck cancer alternative and complementary methodologies diagnosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Raman spectroscopy FTIR spectroscopy breast cancer head and neck cancer alternative and complementary methodologies diagnosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Adriana P. Mamede Inês P. Santos Ana L. M. Batista de Carvalho Paulo Figueiredo Maria C. Silva Mariana V. Tavares Maria P. M. Marques Luís A. E. Batista de Carvalho A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
description	In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients’ prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be an ideal diagnostic method for early cancer diagnosis and surgical margins assessment, as a complement to histopathological analysis. Being highly sensitive, non-invasive and capable of real-time molecular imaging, Raman and Fourier transform infrared (FTIR) spectroscopies give information on the biochemical profile of the tissue under analysis, detecting the metabolic differences between healthy and cancerous portions of the same sample. This constitutes tremendous progress in the field, since the cancer-prompted morphological alterations often occur after the biochemical imbalances in the oncogenic process. Therefore, the early cancer-associated metabolic changes are unnoticed by the histopathologist. Additionally, Raman and FTIR spectroscopies significantly reduce the subjectivity linked to cancer diagnosis. This review focuses on breast and head and neck cancers, their clinical needs and the progress made to date using vibrational spectroscopy as a diagnostic technique prior to surgical intervention and intraoperative margin assessment.
format	article
author	Adriana P. Mamede Inês P. Santos Ana L. M. Batista de Carvalho Paulo Figueiredo Maria C. Silva Mariana V. Tavares Maria P. M. Marques Luís A. E. Batista de Carvalho
author_facet	Adriana P. Mamede Inês P. Santos Ana L. M. Batista de Carvalho Paulo Figueiredo Maria C. Silva Mariana V. Tavares Maria P. M. Marques Luís A. E. Batista de Carvalho
author_sort	Adriana P. Mamede
title	A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
title_short	A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
title_full	A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
title_fullStr	A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
title_full_unstemmed	A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
title_sort	new look into cancer—a review on the contribution of vibrational spectroscopy on early diagnosis and surgery guidance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8fcad4e656b8420685928bb5e9cbf07c
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A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

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