Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis

IntroductionPineal gland tumors are exceedingly rare and account for 0.4-1.0% of brain neoplasms. Their rarity has confounded a clear understanding of the prognostic factors and standards of care for these neoplasms. In this study, we aimed to investigate the incidence, prognostic indicators, and su...

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Autores principales:	Huy Gia Vuong, Tam N. M. Ngo, Ian F. Dunn
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pineal gland brain tumor germ cell tumor pineal parenchymal tumor pineoblastoma glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8fce65d0b6fd4825b28d0df15eca91c7
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spelling	oai:doaj.org-article:8fce65d0b6fd4825b28d0df15eca91c72021-11-19T05:12:10ZIncidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis2234-943X10.3389/fonc.2021.780173https://doaj.org/article/8fce65d0b6fd4825b28d0df15eca91c72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.780173/fullhttps://doaj.org/toc/2234-943XIntroductionPineal gland tumors are exceedingly rare and account for 0.4-1.0% of brain neoplasms. Their rarity has confounded a clear understanding of the prognostic factors and standards of care for these neoplasms. In this study, we aimed to investigate the incidence, prognostic indicators, and survival trend of tumors emanating from the pineal gland.MethodsWe accessed the Surveillance, Epidemiology, End Results (SEER) Program for pineal gland tumors from 1975-2016. A multivariate Cox regression model was used to investigate the impact of clinicopathological parameters on all-cause mortality. For survival trend analysis, we employed the Kaplan Meier curve and pairwise comparisons to examine the trend.ResultsWe found 1,792 and 310,003 pineal gland and brain neoplasms during 1975-2016 resulting in an incidence of 0.6%. In the multivariate Cox proportional hazards model, older age, male gender, non-germ cell tumor, and receipt of chemotherapy were significantly associated with poor survival (p < 0.001). The extent of resection and radiotherapy administration did not produce survival advantages. Our result also highlighted an increased survival of pineal gland tumors over the years.ConclusionOur study investigated the prognostic factors that influenced survival in patients with pineal gland tumors. Chemotherapy use adversely affected patient outcomes and should be considered carefully in specific circumstances to avoid its harmful effects. These findings provide important evidence to improve current standards of care for this rare group of tumors. The survival of pineal tumors has improved over time reflecting improvements in current practice.Huy Gia VuongHuy Gia VuongTam N. M. NgoIan F. DunnFrontiers Media S.A.articlepineal glandbrain tumorgerm cell tumorpineal parenchymal tumorpineoblastomagliomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pineal gland brain tumor germ cell tumor pineal parenchymal tumor pineoblastoma glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pineal gland brain tumor germ cell tumor pineal parenchymal tumor pineoblastoma glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huy Gia Vuong Huy Gia Vuong Tam N. M. Ngo Ian F. Dunn Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
description	IntroductionPineal gland tumors are exceedingly rare and account for 0.4-1.0% of brain neoplasms. Their rarity has confounded a clear understanding of the prognostic factors and standards of care for these neoplasms. In this study, we aimed to investigate the incidence, prognostic indicators, and survival trend of tumors emanating from the pineal gland.MethodsWe accessed the Surveillance, Epidemiology, End Results (SEER) Program for pineal gland tumors from 1975-2016. A multivariate Cox regression model was used to investigate the impact of clinicopathological parameters on all-cause mortality. For survival trend analysis, we employed the Kaplan Meier curve and pairwise comparisons to examine the trend.ResultsWe found 1,792 and 310,003 pineal gland and brain neoplasms during 1975-2016 resulting in an incidence of 0.6%. In the multivariate Cox proportional hazards model, older age, male gender, non-germ cell tumor, and receipt of chemotherapy were significantly associated with poor survival (p < 0.001). The extent of resection and radiotherapy administration did not produce survival advantages. Our result also highlighted an increased survival of pineal gland tumors over the years.ConclusionOur study investigated the prognostic factors that influenced survival in patients with pineal gland tumors. Chemotherapy use adversely affected patient outcomes and should be considered carefully in specific circumstances to avoid its harmful effects. These findings provide important evidence to improve current standards of care for this rare group of tumors. The survival of pineal tumors has improved over time reflecting improvements in current practice.
format	article
author	Huy Gia Vuong Huy Gia Vuong Tam N. M. Ngo Ian F. Dunn
author_facet	Huy Gia Vuong Huy Gia Vuong Tam N. M. Ngo Ian F. Dunn
author_sort	Huy Gia Vuong
title	Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
title_short	Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
title_full	Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
title_fullStr	Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
title_full_unstemmed	Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis
title_sort	incidence, prognostic factors, and survival trend in pineal gland tumors: a population-based analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8fce65d0b6fd4825b28d0df15eca91c7
work_keys_str_mv	AT huygiavuong incidenceprognosticfactorsandsurvivaltrendinpinealglandtumorsapopulationbasedanalysis AT huygiavuong incidenceprognosticfactorsandsurvivaltrendinpinealglandtumorsapopulationbasedanalysis AT tamnmngo incidenceprognosticfactorsandsurvivaltrendinpinealglandtumorsapopulationbasedanalysis AT ianfdunn incidenceprognosticfactorsandsurvivaltrendinpinealglandtumorsapopulationbasedanalysis
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Incidence, Prognostic Factors, and Survival Trend in Pineal Gland Tumors: A Population-Based Analysis

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